Osgin2, an oxidative stress induced factor, is a member of the Osgin gene family involved in the cellular oxidative stress response [7]. Although its exact biochemical role remains undefined, it has been implicated in various cellular processes such as cell proliferation, apoptosis, and autophagy [7].

In osteoporotic rats, oxidative stress leads to up-regulation of Osgin2 in jawbone bone marrow mesenchymal stem cells (BMSCs), restricting their osteogenic ability via regulating RORα. Silence of Osgin2 in these cells ameliorates the osteogenic deficiency, and intra-jawbone infusion of si-OSGIN2 rescues jawbone loss and promotes new bone deposition [1]. In gastric cancer, high levels of Osgin2 are associated with a poor prognosis. Knockdown of Osgin2 inhibits tumor cell proliferation and causes cell cycle arrest [2]. In endothelial cells, cigarette smoke-induced up-regulation of Osgin1 and Osgin2 leads to endothelial detachment, and knockdown of Osgin1&2 inhibits this process [3]. In human dental-pulp-stem-cells-derived neurons, exposure to Ag-NPs changes the mRNA expression level of Osgin2 [4]. In soft-tissue sarcoma, miR-199a-5p regulates the 3'UTR of Osgin2 [5]. In cadmium-induced kidney injury in mice, Tim-3 deficiency impacts the expression of Osgin2 [6]. In colorectal cancer, Osgin2 is one of the oxidative stress-related genes used to build a prognostic risk model [8]. In chicken breeds, Osgin2 is a candidate gene for cold adaptation [9]. In Ningqiang ponies, Osgin2 is associated with bone development [10].

In conclusion, Osgin2 is an important gene involved in multiple biological processes, including osteogenesis, cancer cell proliferation, endothelial cell adhesion, and more. Studies, especially those using loss-of-function models in various species, have revealed its role in different disease conditions and biological functions, highlighting its potential as a therapeutic target and biomarker.