C57BL/6JCya-Erich3em1flox/Cya
Common Name:
Erich3-flox
Product ID:
S-CKO-05472
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Erich3-flox
Strain ID
CKOCMP-209601-Erich3-B6J-VA
Gene Name
Product ID
S-CKO-05472
Gene Alias
1700013E18Rik; 4922501L14Rik; 5031409G23Rik; Gm133
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Erich3em1flox/Cya mice (Catalog S-CKO-05472) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000051862
NCBI RefSeq
NM_175176
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
ERICH3, also known as Glutamate Rich 3, is a gene with significant functions in the body. It has been implicated in vesicular function, especially in serotonergic and other neuronal cell types. This function might be related to antidepressant treatment response. Additionally, ERICH3 is a component of the mammalian primary cilium, regulating cilium length and the ciliary levels of sonic hedgehog signaling molecules [1,2].
In terms of its role in diseases, several studies have focused on its association with major depressive disorder (MDD). Meta-analysis showed that certain SNPs across the ERICH3 gene were significantly associated with SSRI treatment outcomes in MDD patients. ERICH3 may be involved in vesicular function related to serotonin (5-HT), as its knockout in SK-N-SH cells decreased 5-HT staining, and concentrations in the culture media and cell lysates without changing 5-HT synthesizing or metabolizing enzymes. Also, the ERICH3 rs11580409 polymorphism was associated with 6-month antidepressant response in depressed patients [1,3].
In conclusion, ERICH3 plays important roles in vesicular function and primary cilium regulation. Its association with antidepressant treatment response in MDD patients, especially through its potential influence on 5-HT-related vesicular function, makes it a gene of interest in understanding the mechanisms of MDD and developing better treatment strategies.
References：
1. Liu, Duan, Zhuang, Yongxian, Zhang, Lingxin, Wang, Liewei, Weinshilboum, Richard M. 2020. ERICH3: vesicular association and antidepressant treatment response. In Molecular psychiatry, 26, 2415-2428. doi:10.1038/s41380-020-00940-y. https://pubmed.ncbi.nlm.nih.gov/33230203/
2. Alsolami, Mona, Kuhns, Stefanie, Alsulami, Manal, Blacque, Oliver E. 2019. ERICH3 in Primary Cilia Regulates Cilium Formation and the Localisations of Ciliary Transport and Sonic Hedgehog Signaling Proteins. In Scientific reports, 9, 16519. doi:10.1038/s41598-019-52830-1. https://pubmed.ncbi.nlm.nih.gov/31712586/
3. Chappell, Kenneth, Colle, Romain, Ait Tayeb, Abd El Kader, Corruble, Emmanuelle, Verstuyft, Céline. 2022. The ERICH3 rs11580409 polymorphism is associated with 6-month antidepressant response in depressed patients. In Progress in neuro-psychopharmacology & biological psychiatry, 119, 110608. doi:10.1016/j.pnpbp.2022.110608. https://pubmed.ncbi.nlm.nih.gov/35878676/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen