C57BL/6JCya-Tacr1em1flox/Cya
Common Name
Tacr1-flox
Product ID
S-CKO-05704
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-21336-Tacr1-B6J-VA
When using this mouse strain in a publication, please cite “Tacr1-flox Mouse (Catalog S-CKO-05704) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tacr1-flox
Strain ID
CKOCMP-21336-Tacr1-B6J-VA
Gene Name
Product ID
S-CKO-05704
Gene Alias
Spr, Nk1r, Tac1r
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000032122
NCBI RefSeq
NM_009313
Target Region
Exon 4~5
Size of Effective Region
~2.9 kb
Overview of Gene Research
Tacr1, also known as the neurokinin 1 receptor, is a G-protein-coupled receptor. It binds to substance P, a neuropeptide, and is involved in multiple biological pathways. It plays a crucial role in neural circuits related to sexual behavior, pain, and metastasis, and is also associated with alcohol dependence, postoperative nausea and vomiting, and neurovascular coupling [1-9].
In male sexual behavior, Tacr1-expressing neurons in the POA (innervated by BNSTprTac1 neurons) are essential. Activation of POATacr1 neurons can trigger mating even in satiated males and is rewarding [1]. In breast cancer, neuronal substance P acts on tumoral Tacr1 to drive metastasis through a non-canonical pathway [2]. In pain-related studies, Tacr1-expressing neurons form parallel ascending circuits conveying cutaneous signals. Activation of spinal Tacr1-expressing neurons can evoke pain-related behaviors, and PBN-SLTacr1 neurons play a role in ongoing pain sensation [3,4].
In conclusion, Tacr1 is involved in diverse biological processes. Mouse models with Tacr1-related manipulations have revealed its significance in male sexual behavior, cancer metastasis, and pain perception. These findings contribute to understanding the underlying mechanisms of these biological processes and related diseases, potentially guiding the development of targeted therapies.
References：
1. Bayless, Daniel W, Davis, Chung-Ha O, Yang, Renzhi, Luo, Liqun, Shah, Nirao M. 2023. A neural circuit for male sexual behavior and reward. In Cell, 186, 3862-3881.e28. doi:10.1016/j.cell.2023.07.021. https://pubmed.ncbi.nlm.nih.gov/37572660/
2. Padmanaban, Veena, Keller, Isabel, Seltzer, Ethan S, Kerner, Zachary, Tavazoie, Sohail F. 2024. Neuronal substance P drives metastasis through an extracellular RNA-TLR7 axis. In Nature, 633, 207-215. doi:10.1038/s41586-024-07767-5. https://pubmed.ncbi.nlm.nih.gov/39112700/
3. Choi, Seungwon, Hachisuka, Junichi, Brett, Matthew A, Ross, Sarah E, Ginty, David D. 2020. Parallel ascending spinal pathways for affective touch and pain. In Nature, 587, 258-263. doi:10.1038/s41586-020-2860-1. https://pubmed.ncbi.nlm.nih.gov/33116307/
4. Barik, Arnab, Sathyamurthy, Anupama, Thompson, James, Levine, Ariel, Chesler, Alexander. 2021. A spinoparabrachial circuit defined by Tacr1 expression drives pain. In eLife, 10, . doi:10.7554/eLife.61135. https://pubmed.ncbi.nlm.nih.gov/33591273/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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