C57BL/6JCya-Slc6a6em1flox/Cya
Common Name:
Slc6a6-flox
Product ID:
S-CKO-05748
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Slc6a6-flox
Strain ID
CKOCMP-21366-Slc6a6-B6J-VA
Gene Name
Product ID
S-CKO-05748
Gene Alias
Taut
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc6a6em1flox/Cya mice (Catalog S-CKO-05748) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032185
NCBI RefSeq
NM_009320
Target Region
Exon 4~5
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Slc6a6, also known as TauT, is a transmembrane transporter belonging to the solute carrier family 6. It is crucial for maintaining taurine homeostasis as it facilitates the transport of taurine, an amino-acid-like compound involved in various physiological processes such as osmoregulation, antioxidation, and neurotransmission [2,3]. Genetic models, like gene knockout mouse models, are valuable for studying Slc6a6's functions in vivo.
In cancer research, Slc6a6 has been found to be correlated with aggressiveness and poor outcomes in multiple cancers. In gastric cancer, its high expression is associated with poor prognosis, and hypomethylation contributes to its upregulation [1]. In colorectal cancer, SLC6A6 knockdown attenuated cell survival and enhanced drug sensitivity, indicating its role in promoting cell survival and multidrug resistance [5].
In the context of heart failure, Pdk1 deficiency-induced heart failure is related to disturbances in taurine homeostasis triggered by Slc6a6 [2]. Also, in vascular smooth muscle cells, SLC6A6 overexpression suppresses neointimal formation by inhibiting cell proliferation and migration via the Wnt/β-catenin signaling pathway [4].
In conclusion, Slc6a6 is essential for taurine transport and homeostasis, playing important roles in multiple biological processes and disease conditions. Studies using gene knockout or knockdown models have revealed its significance in cancer, heart failure, and vascular remodeling. These findings contribute to our understanding of disease mechanisms and may provide potential therapeutic targets for related diseases.
References:
1. Dazhi, Wang, Jing, Du, Chunling, Ren, Mi, Zhou, Zhixuan, Xia. 2019. Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer. In Biomarkers in medicine, 13, 95-104. doi:10.2217/bmm-2018-0256. https://pubmed.ncbi.nlm.nih.gov/30767502/
2. Li, Chen, Zhou, Yi, Niu, Yan, Song, Weihong, Gao, Hongchang. . Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37, e23134. doi:10.1096/fj.202300272R. https://pubmed.ncbi.nlm.nih.gov/37561545/
3. Kubo, Yoshiyuki, Ishizuka, Sakiko, Ito, Takeru, Akanuma, Shin-Ichi, Hosoya, Ken-Ichi. 2022. Involvement of TauT/SLC6A6 in Taurine Transport at the Blood-Testis Barrier. In Metabolites, 12, . doi:10.3390/metabo12010066. https://pubmed.ncbi.nlm.nih.gov/35050188/
4. Rong, Zhihua, Li, Fengshi, Zhang, Rui, Ni, Leng, Liu, Changwei. 2023. Ant-Neointimal Formation Effects of SLC6A6 in Preventing Vascular Smooth Muscle Cell Proliferation and Migration via Wnt/β-Catenin Signaling. In International journal of molecular sciences, 24, . doi:10.3390/ijms24033018. https://pubmed.ncbi.nlm.nih.gov/36769341/
5. Yasunaga, Masahiro, Matsumura, Yasuhiro. 2014. Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer. In Scientific reports, 4, 4852. doi:10.1038/srep04852. https://pubmed.ncbi.nlm.nih.gov/24781822/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen