Edrf1, also known as erythroid differentiation regulatory factor 1, is a gene with diverse functions. It is involved in erythroid differentiation and regulation of globin gene expression, playing a key role in processes related to blood cell development. In addition, it may have significance in other biological aspects as suggested by its presence in various species like zebrafish during spermatogenesis and in response to hypoxia and reoxygenation stress in the large yellow croaker [4,5,6,7,8,9,10].

In the context of human studies, EDRF1 has been identified as a candidate gene associated with intellectual disability in Middle Eastern families [1]. In dengue virus-related research, it was found to be a substrate of dengue virus protease. The cleavage of EDRF1 by the protease may contribute to thrombocytopenia, a symptom of dengue virus infection. This occurs as EDRF1 regulates GATA1, which controls spectrin synthesis necessary for platelet formation [2,3].

In conclusion, EDRF1 is a gene with functions in multiple biological processes. Its role in erythroid differentiation and globin gene regulation is well-established, and its emerging associations with diseases such as intellectual disability and dengue-related thrombocytopenia highlight its importance in understanding disease mechanisms. The findings from these different models and studies provide valuable insights into the biological functions of EDRF1 and its potential implications in disease-related pathways.