Ccdc28a, a member of the CCDC family proteins, is highly expressed in testes. It plays a crucial role in male reproduction, with its function potentially related to spermatozoa modifications. Its associated pathways may involve those related to sperm development and function, and it holds significant biological importance in male fertility [1].

Two studies using knockout mouse models have revealed its role in male infertility. In one study, Ccdc28a deletion led to bent sperm heads, acrosomal defects, reduced motility, and decreased in vitro fertilization competence, though axoneme, outer dense fibers, and fibrous sheath were normal. CCDC28A was also found to interact with SPACA1 and GSK3A, deficiencies of which also caused sperm head and acrosome abnormalities [1]. Another study showed that Ccdc28a deficiency caused diminished sperm motility and structural aberrations in sperm tails, especially affecting the head-tail coupling apparatus, resulting in male infertility [2].

In conclusion, Ccdc28a is essential for regulating sperm morphology and motility, as demonstrated by gene knockout mouse models. These models have significantly contributed to understanding its role in male infertility, highlighting its importance in this disease area.