C57BL/6JCya-Cfap36em1flox/Cya
Common Name:
Cfap36-flox
Product ID:
S-CKO-06015
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Cfap36-flox
Strain ID
CKOCMP-216618-Cfap36-B6J-VA
Gene Name
Product ID
S-CKO-06015
Gene Alias
2300003H10; 4931428D14Rik; Ccdc104
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cfap36em1flox/Cya mice (Catalog S-CKO-06015) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020754
NCBI RefSeq
NM_025740
Target Region
Exon 2
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Cfap36, also known as CCDC104/BARTL1, is a gene with a protein product that interacts with Arl3, a ciliary protein. Cilia are crucial for many developmental signaling pathways. Cfap36 may be linked to the Arl3 transport network and potentially has a role in ciliary function [1].
In a study on differential transcript usage across mammalian oocytes, Cfap36 was among ten cross-species DTU genes. These genes' functions were found to align with RNA and cell-cycle control mechanisms during oocyte maturation, suggesting Cfap36's importance in this process [2].
In conclusion, Cfap36 seems to play important roles in ciliary function and oocyte maturation. Its study can contribute to a better understanding of the related biological processes, which may potentially shed light on relevant disease areas in the future. [1,2]
References：
1. Lokaj, Mandy, Kösling, Stefanie K, Koerner, Carolin, Boldt, Karsten, Wittinghofer, Alfred. 2015. The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. In Structure (London, England : 1993), 23, 2122-32. doi:10.1016/j.str.2015.08.016. https://pubmed.ncbi.nlm.nih.gov/26455799/
2. Sananmuang, Thanida, Puthier, Denis, Nguyen, Catherine, Chokeshaiusaha, Kaj. 2023. Differential transcript usage across mammalian oocytes at the germinal vesicle and metaphase II stages. In Theriogenology, 215, 1-9. doi:10.1016/j.theriogenology.2023.11.016. https://pubmed.ncbi.nlm.nih.gov/37995439/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen