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C57BL/6NCya-Wrap53em1flox/Cya
Common Name:
Wrap53-flox
Product ID:
S-CKO-06060
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Wrap53-flox
Strain ID
CKOCMP-216853-Wrap53-B6N-VA
Gene Name
Wrap53
Product ID
S-CKO-06060
Gene Alias
Wdr79
Background
C57BL/6NCya
NCBI ID
216853
Modification
Conditional knockout
Chromosome
11
Phenotype
MGI:2384933
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Wrap53em1flox/Cya mice (Catalog S-CKO-06060) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000048139
NCBI RefSeq
NM_144824
Target Region
Exon 3
Size of Effective Region
~0.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Wrap53, also known as WD repeat containing antisense to TP53, encodes an antisense transcript for tumor protein p53 (TP53) stabilization (WRAP53α) and a functional protein (WRAP53β, WDR79, or TCAB1). The WRAP53β protein acts as a scaffolding protein crucial for telomerase localization, telomere assembly, Cajal body integrity, and DNA double-strand break repair. It contains WD40 domains mediating various cell interactions [1].

In an in vivo mouse model of stroke, oxygen/glucose-deprived (OGD) neurons showed that DNA double-strand breaks (DSBs) correlated with WRAP53 up-regulation, which translocated to the nucleus to activate DSB repair response. Neurons expressing the Wrap53 human nonsynonymous single-nucleotide polymorphism (SNP) rs2287499 (c.202C>G) had faster nuclear translocation of WRAP53, and patients with this SNP had less infarct volume and better functional outcome after stroke, indicating WRAP53 promotes DNA repair, neuronal survival, and functional recovery after stroke [2]. In non-small cell lung cancer cells, knockdown of WRAP53-1α and WRAP53-1β had different effects on cell behaviors depending on p53 expression [3]. Low levels of WRAP53 protein predict local recurrence and breast cancer-related death, and low WRAP53 RNA levels may indicate radioresistance [4].

In conclusion, Wrap53 is essential for multiple cellular processes such as telomere-related functions and DNA repair. Studies using in vivo models like the stroke mouse model have revealed its significance in stroke recovery, and its role in cancer-related processes like non-small cell lung cancer cell behaviors and breast cancer prognosis and radioresistance. These findings contribute to understanding the biological functions of Wrap53 in disease conditions, providing potential directions for disease treatment and prevention.

References:
1. Gadelha, Renan Brito, Machado, Caio Bezerra, Pessoa, Flávia Melo Cunha de Pinho, Khayat, André Salim, Moreira-Nunes, Caroline Aquino. 2022. The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset. In Current issues in molecular biology, 44, 5498-5515. doi:10.3390/cimb44110372. https://pubmed.ncbi.nlm.nih.gov/36354684/
2. Sánchez-Morán, Irene, Rodríguez, Cristina, Lapresa, Rebeca, Bolaños, Juan P, Almeida, Angeles. 2020. Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke. In Science advances, 6, . doi:10.1126/sciadv.abc5702. https://pubmed.ncbi.nlm.nih.gov/33028529/
3. Zhu, Yan, Sun, Wenjie, Jiang, Xueping, Gong, Yan, Xie, Conghua. 2023. Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors. In PloS one, 18, e0281132. doi:10.1371/journal.pone.0281132. https://pubmed.ncbi.nlm.nih.gov/36706151/
4. Egelberg, Moa, De Marchi, Tommaso, Pekar, Gyula, Killander, Fredrika, Nimeús, Emma. 2023. Low levels of WRAP53 predict decreased efficacy of radiotherapy and are prognostic for local recurrence and death from breast cancer: a long-term follow-up of the SweBCG91RT randomized trial. In Molecular oncology, 17, 2029-2040. doi:10.1002/1878-0261.13426. https://pubmed.ncbi.nlm.nih.gov/36975842/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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