C57BL/6JCya-Tgfbr1em1flox/Cya
Common Name
Tgfbr1-flox
Product ID
S-CKO-06237
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-21812-Tgfbr1-B6J-VA
When using this mouse strain in a publication, please cite “Tgfbr1-flox Mouse (Catalog S-CKO-06237) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tgfbr1-flox
Strain ID
CKOCMP-21812-Tgfbr1-B6J-VA
Gene Name
Product ID
S-CKO-06237
Gene Alias
ALK5, ESK2, Alk-5, TGFR-1, TbetaRI, TbetaR-I
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000007757
NCBI RefSeq
NM_009370
Target Region
Exon 5~6
Size of Effective Region
~1.2 kb
Overview of Gene Research
Tgfbr1, short for transforming growth factor-beta receptor 1, is a key component in the TGF-β signaling pathway. This pathway is involved in numerous biological processes such as cell growth, differentiation, and extracellular matrix production. Perturbations in TGF-β signaling can lead to various human phenotypes, highlighting the biological importance of Tgfbr1 [1].
In post-myocardial infarction mice, calycosin was found to reduce myocardial fibrosis and improve cardiac function by suppressing the Tgfbr1 signaling pathway. Deletion of Tgfbr1 in cardiac-specific knockout mice partially counteracted the beneficial effects of calycosin, suggesting that Tgfbr1 is crucial in myocardial fibrosis and cardiac dysfunction after myocardial infarction [2]. In bioengineered vascular grafts, a pathogenic TGFBR1 variant (TGFBR1A230T) led to impaired mechanical properties, aneurysm-like formation in vivo, and defects in collagen-related processes, demonstrating the role of Tgfbr1 in vascular integrity and aneurysm development [3].
In conclusion, Tgfbr1 is essential in the TGF-β signaling pathway, influencing multiple biological processes. Studies using gene-knockout mouse models have revealed its significance in diseases like myocardial fibrosis and aneurysm formation. Understanding Tgfbr1's function provides insights into the mechanisms of these diseases and may offer potential therapeutic targets.
References：
1. Loeys, Bart L, Chen, Junji, Neptune, Enid R, De Paepe, Anne M, Dietz, Harry C. 2005. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. In Nature genetics, 37, 275-81. doi:. https://pubmed.ncbi.nlm.nih.gov/15731757/
2. Chen, Guanghong, Xu, Honglin, Xu, Tong, Liu, Bin, Zhou, Yingchun. 2022. Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways. In Phytomedicine : international journal of phytotherapy and phytopharmacology, 104, 154277. doi:10.1016/j.phymed.2022.154277. https://pubmed.ncbi.nlm.nih.gov/35752078/
3. Yang, Ying, Feng, Hao, Tang, Ying, Mizrak, Dogukan, Yang, Bo. 2024. Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects. In Science translational medicine, 16, eadg6298. doi:10.1126/scitranslmed.adg6298. https://pubmed.ncbi.nlm.nih.gov/38718134/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.