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C57BL/6JCya-Eif4e1bem1flox/Cya
Common Name:
Eif4e1b-flox
Product ID:
S-CKO-06261
Background:
C57BL/6JCya
Product Type
Age
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Basic Information
Strain Name
Eif4e1b-flox
Strain ID
CKOCMP-218268-Eif4e1b-B6J-VA
Gene Name
Eif4e1b
Product ID
S-CKO-06261
Gene Alias
Eif4eloo; Gm273
Background
C57BL/6JCya
NCBI ID
218268
Modification
Conditional knockout
Chromosome
13
Phenotype
MGI:2685119
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Eif4e1bem1flox/Cya mice (Catalog S-CKO-06261) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000126785
NCBI RefSeq
NM_001286179.1
Target Region
Exon 4~7
Size of Effective Region
~2.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Eif4e1b, a germline-specific paralog of the eukaryotic translation initiation factor 4E family, plays a crucial role in the translation of maternal mRNAs during oogenesis and early embryogenesis [2,3]. It is involved in the oocyte-to-embryo transition (OET) and zygotic genome activation, and is essential for maintaining the dormancy of maternal mRNAs [2,3].

In gene-edited mice, maternal deletion of Eif4e1b leads to multiple defects in oogenesis and embryonic developmental competence during OET [1]. Eif4e1b-cKO oocytes insufficiently synthesize proteins crucial for oocyte maturation and embryonic development, indicating its importance in selective translation activation [1]. In zebrafish, loss of Eif4e1b results in reduced histone mRNA levels in early gonads, suggesting its role in mRNA storage [2]. In mouse oocytes, knockdown of eIF4E1b in GV-stage oocytes and zygotes significantly reduces the rates of oocyte maturation and blastocyst formation, respectively [4].

In conclusion, Eif4e1b is indispensable for the selective translation activation of maternal mRNAs in mammalian oocytes. Studies using Eif4e1b KO/CKO mouse models have provided insights into its role in oogenesis, embryonic development, and the maternal-to-zygotic transition, potentially contributing to understanding related reproductive disorders.

References:
1. Guo, Jing, Zhao, Hailian, Zhang, Jue, Xue, Yuanchao, Lin, Ge. 2023. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10, e2205500. doi:10.1002/advs.202205500. https://pubmed.ncbi.nlm.nih.gov/36755190/
2. Lorenzo-Orts, Laura, Strobl, Marcus, Steinmetz, Benjamin, Dürnberger, Gerhard, Pauli, Andrea. 2023. eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs. In EMBO reports, 25, 404-427. doi:10.1038/s44319-023-00006-4. https://pubmed.ncbi.nlm.nih.gov/38177902/
3. Yang, Guanghui, Xin, Qiliang, Feng, Iris, Wu, Di, Dean, Jurrien. 2023. Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. In Genes & development, 37, 418-431. doi:10.1101/gad.350400.123. https://pubmed.ncbi.nlm.nih.gov/37257918/
4. Ma, Zengyou, Zhang, Yanyan, Tian, Xueqi, Lu, Wenjie, Peng, Hui. 2025. EIF4E1B interacts with HSPA1A and PPP2CA and is involved in mouse oocyte maturation and early embryonic development. In Theriogenology, 240, 117398. doi:10.1016/j.theriogenology.2025.117398. https://pubmed.ncbi.nlm.nih.gov/40139147/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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