C57BL/6JCya-Rarbem1flox/Cya
Common Name
Rarb-flox
Product ID
S-CKO-06320
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-218772-Rarb-B6J-VA
When using this mouse strain in a publication, please cite “Rarb-flox Mouse (Catalog S-CKO-06320) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Rarb-flox
Strain ID
CKOCMP-218772-Rarb-B6J-VA
Gene Name
Product ID
S-CKO-06320
Gene Alias
A830025K23, Hap, Nr1b2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000063750
NCBI RefSeq
NM_011243
Target Region
Exon 2
Size of Effective Region
~1.6 kb
Overview of Gene Research
Rarb, or retinoic acid receptor beta, is a transcriptional regulator crucial for coordinating retinoic acid (RA)-mediated morphogenic movements, cell growth, and differentiation [4]. It is involved in the retinoic acid signaling pathway, which has significant importance in multiple biological processes including eye development, hematopoiesis, and neural development [4,5,6]. Genetic models such as knockout (KO) or conditional knockout (CKO) mouse models can be valuable for studying its functions.
In gastric cancer, knockdown of Rarb in vitro accelerated cancer cell proliferation, invasion, and migration, and promoted epithelial-mesenchymal transition (EMT) [1]. In acute promyelocytic leukemia (APL), the majority of RARA-negative APL cases had RARB translocations, and the TBL1XR1-RARB fusion protein exerted similar oncogenic effects to PML-RARA, although the response to retinoids was attenuated [2]. In colorectal carcinoma, overexpression of Rarb inhibited the properties of cancer stem cells (CSCs) and enhanced radiotherapy sensitivity, and DNA methylation inhibitor treatment improved radiotherapy sensitivity by promoting Rarb expression [3].
In conclusion, Rarb plays essential roles in multiple biological processes including cell growth, differentiation, and development. Through model-based research, it has been shown to be involved in various disease conditions such as gastric cancer, APL, and colorectal carcinoma. Understanding Rarb's functions can provide insights into disease mechanisms and potential therapeutic targets.
References：
1. Cai, Xufan, Lin, Wenfa, Wu, Fang, Qian, Zhenyuan, Wang, Yu. 2024. RARB associated with MSI, affects progression and prognosis of gastric cancer. In BMC gastroenterology, 24, 285. doi:10.1186/s12876-024-03339-z. https://pubmed.ncbi.nlm.nih.gov/39179979/
2. Osumi, Tomoo, Tsujimoto, Shin-Ichi, Tamura, Moe, Goyama, Susumu, Kato, Motohiro. 2018. Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation. In Cancer research, 78, 4452-4458. doi:10.1158/0008-5472.CAN-18-0840. https://pubmed.ncbi.nlm.nih.gov/29921692/
3. Shu, Yuxian, Lan, Jun, Hu, Zhaobing, Liu, Weiguo, Song, Rongfeng. . Epigenetic regulation of RARB overcomes the radio-resistance of colorectal carcinoma cells via cancer stem cells. In Journal of radiation research, 64, 11-23. doi:10.1093/jrr/rrac060. https://pubmed.ncbi.nlm.nih.gov/36214504/
4. Replogle, Maria R, Thompson, Samuel, Reis, Linda M, Semina, Elena V. 2024. A De Novo Noncoding RARB Variant Associated with Complex Microphthalmia Alters a Putative Regulatory Element. In Human mutation, 2024, . doi:10.1155/2024/6619280. https://pubmed.ncbi.nlm.nih.gov/39450403/
5. Schönberger, Katharina, Obier, Nadine, Romero-Mulero, Mari Carmen, Pearce, Erika L, Cabezas-Wallscheid, Nina. 2021. Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity. In Cell stem cell, 29, 131-148.e10. doi:10.1016/j.stem.2021.10.002. https://pubmed.ncbi.nlm.nih.gov/34706256/
6. Shibata, Mikihito, Pattabiraman, Kartik, Lorente-Galdos, Belen, Sousa, Andre M M, Sestan, Nenad. 2021. Regulation of prefrontal patterning and connectivity by retinoic acid. In Nature, 598, 483-488. doi:10.1038/s41586-021-03953-x. https://pubmed.ncbi.nlm.nih.gov/34599305/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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