C57BL/6JCya-Tpt1em1flox/Cya
Common Name
Tpt1-flox
Product ID
S-CKO-06459
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-22070-Tpt1-B6J-VA
When using this mouse strain in a publication, please cite “Tpt1-flox Mouse (Catalog S-CKO-06459) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tpt1-flox
Strain ID
CKOCMP-22070-Tpt1-B6J-VA
Gene Name
Product ID
S-CKO-06459
Gene Alias
Trt, p21, p23, TCTP
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000110894
NCBI RefSeq
NM_009429
Target Region
Exon 3~5
Size of Effective Region
~1.7 kb
Overview of Gene Research
TPT1, also known as translationally controlled tumor protein (TCTP), HRF, and fortilin, is a highly conserved gene across eukaryotic species. The protein it encodes is ubiquitously expressed and influences various cellular processes. It is involved in pathways such as those related to phenotypic reprogramming, interacting with key proteins like p53, MCL1, and immunoglobulins. TPT1 is also an essential phosphotransferase in pre-tRNA splicing, releasing mature tRNA and participating in ADP-ribose processes [1,2,3].
In the context of diseases, TPT1 shows potential as a biomarker. Its dysregulation has been linked to a wide range of diseases. For instance, in breast cancer, it has been identified as a prognostic factor and a regulator of the tumor suppressor p53 and cancer stem cell compartment. In pediatric astrocytomas, studies on polymorphisms in the TPT1 gene and its associated molecular pathways suggest a possible association with tumorigenesis risk [1,2,4].
In conclusion, TPT1 is a multifunctional gene involved in crucial cellular processes like tRNA splicing and in the context of diseases, shows promise as a biomarker and potential therapeutic target. Research on TPT1, including through studies on gene polymorphisms in diseases such as pediatric astrocytomas, contributes to understanding disease mechanisms and developing new treatment strategies.
References：
1. Amson, Robert, Pece, Salvatore, Marine, Jean-Christophe, Di Fiore, Pier Paolo, Telerman, Adam. 2012. TPT1/ TCTP-regulated pathways in phenotypic reprogramming. In Trends in cell biology, 23, 37-46. doi:10.1016/j.tcb.2012.10.002. https://pubmed.ncbi.nlm.nih.gov/23122550/
2. Miao, Gelan, Yang, Yulian, Yang, Xuelian, Liu, Li, Lei, Xianying. 2024. The multifaceted potential of TPT1 as biomarker and therapeutic target. In Heliyon, 10, e38819. doi:10.1016/j.heliyon.2024.e38819. https://pubmed.ncbi.nlm.nih.gov/39397949/
3. Yang, Shiquan, Qu, Gaoyi, Fu, Bixia, Peng, Dan, Zhou, Bo. . The function of KptA/Tpt1 gene - a minor review. In Functional plant biology : FPB, 47, 577-591. doi:10.1071/FP19159. https://pubmed.ncbi.nlm.nih.gov/32438974/
4. Morais de Castro, Eduardo, Barbosa, Leonardo Vinícius, Simoneti Fonseca, Aline, de Noronha, Lucia, Machado-Souza, Cleber. . Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas. In ASN neuro, 15, 17590914231153481. doi:10.1177/17590914231153481. https://pubmed.ncbi.nlm.nih.gov/36714975/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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