Ezr, a member of the ERM (ezrin-radixin-moesin) protein family, acts as a regulator of adhesion signal pathways [1]. It is involved in biological processes such as cell adhesion, ameboidal-type cell migration, and cell junction assembly. Pathways like pancreatic cancer pathway and adhesion junction pathway are enriched in EZR-regulated pathological processes [1].

In pancreatic cancer, EZR is highly expressed and promotes cancer cell proliferation, migration, and invasion via the FAK/AKT signaling pathway [1]. In ovarian cancer, anti-EZR autoantibody shows potential as a diagnostic marker, with a panel of anti-CFL1, anti-EZR, and anti-CYPA autoantibodies having certain area under the receiver operating characteristic curve, sensitivity, and specificity [2]. In vitiligo-related research, SIRT7 inhibits melanin synthesis in melanocytes by suppressing the succinylation of EZR [3].

In conclusion, Ezr plays crucial roles in multiple biological processes and disease conditions. Its involvement in adhesion-related processes and various signaling pathways in diseases like pancreatic and ovarian cancer, as well as in melanin synthesis in vitiligo, showcases its importance. Research on Ezr provides insights into disease mechanisms and potential diagnostic and treatment strategies.