C57BL/6JCya-Ezrem1flox/Cya
Common Name
Ezr-flox
Product ID
S-CKO-06610
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-22350-Ezr-B6J-VA
When using this mouse strain in a publication, please cite “Ezr-flox Mouse (Catalog S-CKO-06610) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ezr-flox
Strain ID
CKOCMP-22350-Ezr-B6J-VA
Gene Name
Product ID
S-CKO-06610
Gene Alias
p81, Vil2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000064234
NCBI RefSeq
NM_009510
Target Region
Exon 3~5
Size of Effective Region
~2.5 kb
Overview of Gene Research
Ezr, a member of the ERM (ezrin-radixin-moesin) protein family, acts as a regulator of adhesion signal pathways [1]. It is involved in biological processes such as cell adhesion, ameboidal-type cell migration, and cell junction assembly. Pathways like pancreatic cancer pathway and adhesion junction pathway are enriched in EZR-regulated pathological processes [1].
In pancreatic cancer, EZR is highly expressed and promotes cancer cell proliferation, migration, and invasion via the FAK/AKT signaling pathway [1]. In ovarian cancer, anti-EZR autoantibody shows potential as a diagnostic marker, with a panel of anti-CFL1, anti-EZR, and anti-CYPA autoantibodies having certain area under the receiver operating characteristic curve, sensitivity, and specificity [2]. In vitiligo-related research, SIRT7 inhibits melanin synthesis in melanocytes by suppressing the succinylation of EZR [3].
In conclusion, Ezr plays crucial roles in multiple biological processes and disease conditions. Its involvement in adhesion-related processes and various signaling pathways in diseases like pancreatic and ovarian cancer, as well as in melanin synthesis in vitiligo, showcases its importance. Research on Ezr provides insights into disease mechanisms and potential diagnostic and treatment strategies.
References：
1. Xu, Jian, Zhang, Wei. 2021. EZR promotes pancreatic cancer proliferation and metastasis by activating FAK/AKT signaling pathway. In Cancer cell international, 21, 521. doi:10.1186/s12935-021-02222-1. https://pubmed.ncbi.nlm.nih.gov/34627255/
2. Cheng, Yifan, Li, Qing, Sun, Guiying, Shi, Jianxiang, Wang, Peng. 2024. Serum anti-CFL1, anti-EZR, and anti-CYPA autoantibody as diagnostic markers in ovarian cancer. In Scientific reports, 14, 9757. doi:10.1038/s41598-024-60544-2. https://pubmed.ncbi.nlm.nih.gov/38684875/
3. Ma, Yuehong, Chang, Hongqin. 2024. SIRT7 Inhibits Melanin Synthesis of PIG1 and PIG3V by Suppressing the Succinylation of EZR. In Clinical, cosmetic and investigational dermatology, 17, 1495-1504. doi:10.2147/CCID.S462280. https://pubmed.ncbi.nlm.nih.gov/38933605/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.