C57BL/6JCya-Pgm5em1flox/Cya
Common Name
Pgm5-flox
Product ID
S-CKO-06888
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-226041-Pgm5-B6J-VA
Status
When using this mouse strain in a publication, please cite “Pgm5-flox Mouse (Catalog S-CKO-06888) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Pgm5-flox
Strain ID
CKOCMP-226041-Pgm5-B6J-VA
Gene Name
Product ID
S-CKO-06888
Gene Alias
aciculin, 4833423B07, D830025G17, 9530034F03Rik
Background
C57BL/6JCya
Gene Full Name
phosphoglucomutase 5
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 19 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000047666
NCBI Transcript ID
NM_175013
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Overview of Gene Research
Pgm5, phosphoglucomutase-like protein 5, is a metabolic enzyme involved in the metabolism of glucose-1-phosphate and glucose-6-phosphate [1,2]. Although its exact function and associated pathways are still being explored, metabolic enzymes like Pgm5 are crucial for maintaining normal cellular metabolic processes, which are essential for cell survival, growth, and differentiation. Genetic models, such as gene knockout (KO) or conditional knockout (CKO) mouse models, could potentially be valuable in further understanding its function.
Multiple studies have explored Pgm5's role in various cancers. In liver cancer, PGM5 expression was significantly lower in cancerous than adjacent normal liver tissues, and had modest diagnostic value. Its expression had positive associations with male sex and survival, but negative associations with advanced disease features. Low PGM5 levels were associated with poorer overall survival and relapse-free survival, indicating it may be a diagnostic and prognostic biomarker [1].
In colorectal cancer, PGM5 protein levels were lower in cancer tissues, and low PGM5 expression was associated with poor overall survival. Overexpression of PGM5 inhibited CRC cell proliferation, invasion, and migration, while knockdown promoted these processes, suggesting PGM5 is a promising biomarker in CRC [2].
In prostate cancer, PGM5 expression was significantly lower in cancer tissue, and its low expression was linked to poor clinical outcome and high Gleason score. Overexpression of PGM5 repressed prostate cancer cell proliferation and migration [3].
In conclusion, Pgm5 appears to play a role in cancer development and prognosis across multiple cancer types. Studies in these cancer models suggest that Pgm5 may act as a suppressor of tumor cell proliferation, invasion, and migration. The findings from these model-based research contribute to understanding the role of Pgm5 in cancer-related biological processes, providing potential new targets for cancer diagnosis and treatment.
References：
1. Jiao, Yan, Li, Yanqing, Jiang, Peiqiang, Han, Wei, Liu, Yahui. 2019. PGM5: a novel diagnostic and prognostic biomarker for liver cancer. In PeerJ, 7, e7070. doi:10.7717/peerj.7070. https://pubmed.ncbi.nlm.nih.gov/31218127/
2. Sun, Yifan, Long, Haihua, Sun, Lin, Liang, Tianwei, Shen, Yongqi. 2019. PGM5 is a promising biomarker and may predict the prognosis of colorectal cancer patients. In Cancer cell international, 19, 253. doi:10.1186/s12935-019-0967-y. https://pubmed.ncbi.nlm.nih.gov/31582909/
3. Sun, Jian, Wang, Fei, Zhou, Huihui, Fan, Caibin, Wang, Jianqing. 2022. Downregulation of PGM5 expression correlates with tumor progression and poor prognosis in human prostate cancer. In Discover oncology, 13, 63. doi:10.1007/s12672-022-00525-x. https://pubmed.ncbi.nlm.nih.gov/35819729/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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