C57BL/6JCya-Zfp207em1flox/Cya
Common Name:
Zfp207-flox
Product ID:
S-CKO-06989
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Zfp207-flox
Strain ID
CKOCMP-22680-Zfp207-B6J-VA
Gene Name
Product ID
S-CKO-06989
Gene Alias
8430401D15Rik; BuGZ; Zep; Znf207
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp207em1flox/Cya mice (Catalog S-CKO-06989) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000053740
NCBI RefSeq
NM_001130169
Target Region
Exon 3
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Zfp207, a zinc finger protein, is essential for mammalian embryonic development [1]. It is involved in multiple biological processes such as maintaining pluripotency in mouse embryonic stem cells (ESCs), coordinating meiotic chromosome alignment in mouse oocytes, and regulating spliceosome assembly [1,2,3]. In plants, it acts as a transcriptional repressor of the green revolution gene SD1/OsGA20ox2 in rice, influencing plant growth and development [4].
In mouse models, silencing of Zfp207 in ESCs leads to severe neuroectodermal differentiation defects, highlighting its role in ESC maintenance [1]. Depletion of Zfp207 in mouse oocytes results in impaired spindle organization, misaligned chromosomes, defective kinetochore-microtubule attachments, and increased aneuploid metaphase II eggs, indicating its importance in meiotic chromosome alignment and spindle assembly checkpoint (SAC) function [2]. Aging-related aneuploidy in mouse oocytes is associated with changes in Zfp207 expression, suggesting its link to mitochondrial imbalance and spindle assembly failure [5].
In conclusion, Zfp207 plays crucial roles in maintaining cell pluripotency, regulating meiotic processes in oocytes, and influencing plant growth. Mouse gene knockout or knockdown models have been instrumental in revealing these functions, providing insights into developmental processes and potential implications in aneuploid-related conditions [1,2,5].
References:
1. Malla, Sandhya, Prasad Bhattarai, Devi, Groza, Paula, Kutter, Claudia, Aguilo, Francesca. 2022. ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. In EMBO reports, 23, e53191. doi:10.15252/embr.202153191. https://pubmed.ncbi.nlm.nih.gov/35037361/
2. Dai, Xiao Xin, Xiong, Hao, Zhang, Mianqun, Sun, Shaochen, Xiong, Bo. . Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes. In Oncotarget, 7, 30155-65. doi:10.18632/oncotarget.9310. https://pubmed.ncbi.nlm.nih.gov/27177335/
3. Zhou, Yuenan, Tong, Chong, Shi, Zuokun, Li, Xiaoyu, Yin, Yafei. 2025. Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly. In Nature structural & molecular biology, , . doi:10.1038/s41594-025-01501-z. https://pubmed.ncbi.nlm.nih.gov/40050462/
4. Duan, Min, Ke, Xiao-Juan, Lan, Hong-Xia, Zhang, Hong-Sheng, Huang, Ji. . A Cys2/His2 Zinc Finger Protein Acts as a Repressor of the Green Revolution Gene SD1/OsGA20ox2 in Rice (Oryza sativa L.). In Plant & cell physiology, 61, 2055-2066. doi:10.1093/pcp/pcaa120. https://pubmed.ncbi.nlm.nih.gov/32966570/
5. Zhang, Fa-Li, Li, Wei-Dong, Zhu, Ke-Xin, Lee, Tin-Lap, Shen, Wei. 2023. Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly. In Cell death discovery, 9, 235. doi:10.1038/s41420-023-01539-2. https://pubmed.ncbi.nlm.nih.gov/37422452/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen