C57BL/6JCya-Stradbem1flox/Cya
Common Name:
Stradb-flox
Product ID:
S-CKO-07034
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Stradb-flox
Strain ID
CKOCMP-227154-Stradb-B6J-VA
Gene Name
Product ID
S-CKO-07034
Gene Alias
Als2cr2; B830008M19; D1Ucla2; ILPIP; ILPIPA; PRO1038; Papk; Syradb
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Stradbem1flox/Cya mice (Catalog S-CKO-07034) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000027185
NCBI RefSeq
NM_172656
Target Region
Exon 4
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Stradb is a gene whose functions are being explored through various research. While specific essential functions, common aliases, and associated pathways aren't clearly detailed in the provided references, its role in multiple biological contexts is emerging. It may be involved in pathways related to drug-induced toxicity, stress responses, and cell-function regulation, highlighting its overall biological importance in understanding physiological and pathological processes [1,2].
In HepG2 cells treated with high concentrations of clopidogrel, the target mRNA STRADB was downregulated, suggesting its involvement in clopidogrel-induced hepatotoxicity as miR-26a-5p, which targets STRADB, was also modulated [1]. In a study on acute psychological stress in healthy women, STRADB was among the genes downregulated in the experimental group experiencing stress induction compared to the control group [2]. In primary lung fibroblasts, STRADB was identified as a target gene of miR-455-3p, which was induced by TGF-β1, indicating its potential role in lung-related functions and diseases [3]. In ovarian cancer cells treated with disodium pentaborate decahydrate, STRADB was downregulated, suggesting its possible connection to the anti-cancer properties of this compound through the PI3K/AKT/mTOR pathway [4].
In conclusion, STRADB seems to be involved in processes related to drug-induced hepatotoxicity, psychological stress responses, lung-fibroblast function, and ovarian cancer cell regulation. Although no KO/CKO mouse model-based findings were in the references, these studies on cell lines and human samples indicate that STRADB may play a significant role in these disease-associated biological processes, and further functional studies, potentially including gene-knockout models, could help to clarify its exact functions and implications in these areas.
References:
1. de Freitas, Renata C Costa, Bortolin, Raul H, Lopes, Mariana B, Luchessi, Augusto D, Luchessi, André D. 2017. Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells. In Frontiers in pharmacology, 8, 906. doi:10.3389/fphar.2017.00906. https://pubmed.ncbi.nlm.nih.gov/29311920/
2. Logan, Jeongok G, Yun, Sijung, Teachman, Bethany A, Farber, Emily, Farber, Charles R. 2022. Genome-Wide mRNA Expression Analysis of Acute Psychological Stress Responses. In MEDICC review, 24, 35-42. doi:10.37757/mr2022.v24.n2.6. https://pubmed.ncbi.nlm.nih.gov/35648061/
3. Ong, Jennie, Timens, Wim, Rajendran, Vijay, Kluiver, Joost, Brandsma, Corry-Anke. 2017. Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. In PloS one, 12, e0183815. doi:10.1371/journal.pone.0183815. https://pubmed.ncbi.nlm.nih.gov/28910321/
4. Gunel, Nur Selvi, Yildirim, Nuri, Ozates, Neslihan Pinar, Korkmaz, Mehmet, Biray Avci, Cigir. 2022. Investigation of cytotoxic and apoptotic effects of disodium pentaborate decahydrate on ovarian cancer cells and assessment of gene profiling. In Medical oncology (Northwood, London, England), 40, 8. doi:10.1007/s12032-022-01870-1. https://pubmed.ncbi.nlm.nih.gov/36308567/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen