C57BL/6JCya-Obp2aem1flox/Cya
Common Name:
Obp2a-flox
Product ID:
S-CKO-07084
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Obp2a-flox
Strain ID
CKOCMP-227627-Obp2a-B6J-VA
Gene Name
Product ID
S-CKO-07084
Gene Alias
Lcn13
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Obp2aem1flox/Cya mice (Catalog S-CKO-07084) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000077667
NCBI RefSeq
NM_153558
Target Region
Exon 2~3
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Obp2a, an odorant-binding protein, has diverse functions. It is involved in processes such as epidermal barrier function and may play a role in lipid metabolism [2,3]. In the epidermal keratinocytes, it protects against cytotoxic small hydrophobic molecules and regulates epidermal barrier function [2].
In prostate cancer, tumor-derived OBP2A promotes castration-resistant prostate cancer (CRPC) development. Knockdown of OBP2A significantly inhibits CRPC and metastatic CRPC development, and improves the therapeutic efficacy of CTLA-4/PD-1 antibodies [1]. Treatment with OBP2A-binding ligand α-pinene can interrupt the function of OBP2A and suppress CRPC development.
In conclusion, Obp2a is crucial for maintaining epidermal barrier function and has a significant impact on prostate cancer development. The gene knockdown studies in relevant models have revealed its role in these biological processes, providing potential therapeutic strategies for advanced prostate cancer.
References：
1. Jeong, Ji-Hak, Zhong, Shangwei, Li, Fuzhuo, Dhillon, Jasreman, Luo, Jun-Li. 2022. Tumor-derived OBP2A promotes prostate cancer castration resistance. In The Journal of experimental medicine, 220, . doi:10.1084/jem.20211546. https://pubmed.ncbi.nlm.nih.gov/36547668/
2. Nakanishi, Shinobu, Hasegawa, Tatsuya, Maeno, Katsuyuki, Motoyama, Akira, Denda, Mitsuhiro. 2024. OBP2A regulates epidermal barrier function and protects against cytotoxic small hydrophobic molecules. In iScience, 27, 111093. doi:10.1016/j.isci.2024.111093. https://pubmed.ncbi.nlm.nih.gov/39502293/
3. Wei, Mengqiu, Li, Peng, Guo, Kai. 2019. The impact of PSRC1 overexpression on gene and transcript expression profiling in the livers of ApoE-/- mice fed a high-fat diet. In Molecular and cellular biochemistry, 465, 125-139. doi:10.1007/s11010-019-03673-x. https://pubmed.ncbi.nlm.nih.gov/31838625/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen