Ikzf3, also known as Aiolos, is a key zinc finger transcription factor in the Ikaros family. It plays a crucial role in modulating a wide range of cell functions, the production of inflammatory mediators, and is involved in multiple biological processes [3].

In multiple myeloma, lenalidomide causes selective ubiquitination and degradation of Ikzf3 by the CRBN-CRL4 ubiquitin ligase, and Ikzf3 is essential for multiple myeloma cells [1,5]. Knocking out Ikzf3 in HER2-specific CAR T cells targeting breast cancer cells enhanced their killing ability both in vitro and in a xenograft model, associated with increased T cell activation and proliferation [4]. In the context of HIV-1, Ikzf3 promotes the survival of transcriptionally active HIV-1-infected cells and thus HIV-1 persistence [2]. In cerebral ischemia/reperfusion injury, knockdown of Ikzf3 exacerbated the damage by regulating inflammatory factors and promoting NF-κB phosphorylation and nuclear transfer [3].

In conclusion, Ikzf3 is a significant transcription factor involved in multiple biological processes and diseases. Its study through gene knockout models has revealed its roles in cancer, viral persistence, and neurological injury, providing insights into potential therapeutic targets for these conditions.