C57BL/6JCya-BC028528em1flox/Cya
Common Name:
BC028528-flox
Product ID:
S-CKO-07266
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
BC028528-flox
Strain ID
CKOCMP-229600-BC028528-B6J-VA
Gene Name
Product ID
S-CKO-07266
Gene Alias
L259
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-BC028528em1flox/Cya mice (Catalog S-CKO-07266) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000090476
NCBI RefSeq
NM_153513
Target Region
Exon 1~2
Size of Effective Region
~3.0 kb
Detailed Document
Overview of Gene Research
BC028528 is an alias for C1orf54, a gene encoding a protein that is highly expressed in kidney tubular epithelial cells (TECs) and has a role in the PI3K/AKT signaling pathway [1]. It is crucial for kidney health and potentially for understanding acute kidney injury (AKI) related biological processes.
In C1orf54-knockout mice, after kidney ischaemia-reperfusion injury (IRI), TEC proliferation was impaired and recovery was delayed, leading to deteriorated renal function and increased mortality [1]. Conversely, adenovirus-mediated C1orf54 overexpression promoted TEC proliferation, ameliorated kidney pathology, and improved renal function [1].
In conclusion, C1orf54, also known as BC028528, is essential for TEC proliferation through the PI3K/AKT signaling pathway, playing a key role in the recovery from kidney IRI. The C1orf54-knockout mouse model has revealed its significance in the context of acute kidney injury, highlighting its potential as a therapeutic target for this disease [1].
References：
1. Xie, Hongyang, Wang, Yaqiong, Zhang, Hang, Zhang, Ruiyan, Yan, Xiaoxiang. 2018. Tubular epithelial C1orf54 mediates protection and recovery from acute kidney injury. In Journal of cellular and molecular medicine, 22, 4985-4996. doi:10.1111/jcmm.13765. https://pubmed.ncbi.nlm.nih.gov/29999589/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen