Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Rbm15em1flox/Cya
Common Name:
Rbm15-flox
Product ID:
S-CKO-07280
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Rbm15-flox
Strain ID
CKOCMP-229700-Rbm15-B6N-VA
Gene Name
Rbm15
Product ID
S-CKO-07280
Gene Alias
C230088J01Rik; mKIAA1438
Background
C57BL/6NCya
NCBI ID
229700
Modification
Conditional knockout
Chromosome
3
Phenotype
MGI:2443205
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Rbm15em1flox/Cya mice (Catalog S-CKO-07280) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000061772
NCBI RefSeq
NM_001045807
Target Region
Exon 1
Size of Effective Region
~3.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rbm15, an RNA-binding protein, is a crucial "writer" of the m6A methyltransferase complex. N6-methyladenosine (m6A) is a prevalent and conserved internal cotranscriptional modification in eukaryotic RNAs. Rbm15 regulates multiple signal pathways such as Notch and Wnt, playing important roles in cell growth, apoptosis, especially in blood cells [3].

In laryngeal squamous cell carcinoma (LSCC), knockdown of Rbm15 reduced cell proliferation, invasion, migration, and promoted apoptosis both in vitro and in vivo, as it regulates TMBIM6 stability through an IGF2BP3-dependent mechanism [1]. In lung adenocarcinoma, overexpression of Rbm15 increased m6A levels and promoted cell invasion, migration, and proliferation, while knockdown had opposite effects. Rbm15-mediated m6A modification inhibits RASSF8 protein levels to increase cell invasion and migration [2]. In triple-negative breast cancer, Rbm15 drives cell growth by stimulating serine and glycine metabolism [4]. In lung cancer, Rbm15 silencing promoted ferroptosis by regulating the TGF-β/Smad2 pathway, reducing cell viability, proliferation, invasion, and migration [5]. In lung adenocarcinoma, Rbm15 overexpression facilitated osimertinib resistance by enhancing m6A modification of SPOCK1 mRNA [6].

In conclusion, Rbm15 is significantly involved in the development and progression of multiple cancers, playing a key role in processes like cell proliferation, invasion, migration, apoptosis, and drug resistance. The study of Rbm15 through gene-knockout or knockdown models in these cancer-related disease areas has provided valuable insights into its functions, offering potential therapeutic targets for cancer treatment.

References:
1. Wang, Xin, Tian, Linli, Li, Yushan, Wang, Peng, Sun, Yanan. 2021. RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. In Journal of experimental & clinical cancer research : CR, 40, 80. doi:10.1186/s13046-021-01871-4. https://pubmed.ncbi.nlm.nih.gov/33637103/
2. Ma, Mingsheng, Wang, Wei, Li, Li, Zhao, Guangqiang, Ye, Lianhua. 2024. RBM15 facilities lung adenocarcinoma cell progression by regulating RASSF8 stability through N6 Methyladenosine modification. In Translational oncology, 46, 102018. doi:10.1016/j.tranon.2024.102018. https://pubmed.ncbi.nlm.nih.gov/38838436/
3. Hu, Mengyu, Yang, Yuxia, Ji, Zhi, Luo, Jianyuan. . RBM15 Functions in Blood Diseases. In Current cancer drug targets, 16, 579-85. doi:. https://pubmed.ncbi.nlm.nih.gov/26758534/
4. Park, Su Hwan, Ju, Jin-Sung, Woo, Hyunmin, Lee, Jong-Ho, Park, Yun-Yong. 2024. The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism. In Experimental & molecular medicine, 56, 1373-1387. doi:10.1038/s12276-024-01235-w. https://pubmed.ncbi.nlm.nih.gov/38825643/
5. Feng, Jing, Li, Yaling, He, Fen, Zhang, Fuwei. 2023. RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer. In Environmental toxicology, 38, 950-961. doi:10.1002/tox.23741. https://pubmed.ncbi.nlm.nih.gov/36715115/
6. Li, Hongxiang, Li, Yin, Zheng, Xiaoxiao, Cheng, Xinghua, Xu, Guodong. 2024. RBM15 facilitates osimertinib resistance of lung adenocarcinoma through m6A-dependent epigenetic silencing of SPOCK1. In Oncogene, 44, 307-321. doi:10.1038/s41388-024-03220-z. https://pubmed.ncbi.nlm.nih.gov/39528815/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest