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C57BL/6JCya-Cyb5rlem1flox/Cya
Common Name:
Cyb5rl-flox
Product ID:
S-CKO-07342
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Price:
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Basic Information
Strain Name
Cyb5rl-flox
Strain ID
CKOCMP-230582-Cyb5rl-B6J-VA
Gene Name
Cyb5rl
Product ID
S-CKO-07342
Gene Alias
2810410C14Rik
Background
C57BL/6JCya
NCBI ID
230582
Modification
Conditional knockout
Chromosome
4
Phenotype
MGI:1919657
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cyb5rlem1flox/Cya mice (Catalog S-CKO-07342) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000106758
NCBI RefSeq
NM_001346552
Target Region
Exon 4
Size of Effective Region
~1.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cyb5rl, a cytochrome b5 reductase homologue, likely plays a role in maintaining normal cell redox balance and related processes in organisms. However, its exact associated pathways and overall biological importance are yet to be fully elucidated, and genetic models could be valuable for further study.

In a study on a dog with extreme intestinal polyposis, a germline mutation R51X of Cyb5rl was found. Bacteroides uniformis, a commensal gut anaerobe, thrived and expressed abundantly thioredoxin and nitroreductase. These bacterial products could reduce oxidative stress linked to this Cyb5rl germline mutation, decreasing cell death, thus contributing to the development of extreme intestinal polyposis [1].

In conclusion, the germline mutation of Cyb5rl in the dog model was associated with oxidative stress reduction and decreased cell death, contributing to extreme intestinal polyposis. This indicates that Cyb5rl may play a role in maintaining cellular redox homeostasis and cell death regulation, and its dysregulation could potentially be involved in certain disease processes such as extreme intestinal polyposis.

References:
1. Wang, Jin, Wang, Tianfang, Bishop, Micah A, Bryan, Laura K, Zhao, Shaying. 2018. Collaborating genomic, transcriptomic and microbiomic alterations lead to canine extreme intestinal polyposis. In Oncotarget, 9, 29162-29179. doi:10.18632/oncotarget.25646. https://pubmed.ncbi.nlm.nih.gov/30018743/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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