C57BL/6JCya-Leng8em1flox/Cya
Common Name:
Leng8-flox
Product ID:
S-CKO-07581
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Leng8-flox
Strain ID
CKOCMP-232798-Leng8-B6J-VA
Gene Name
Product ID
S-CKO-07581
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Leng8em1flox/Cya mice (Catalog S-CKO-07581) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000037472
NCBI RefSeq
NM_172736
Target Region
Exon 3~4
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Check the content of the review
Leng8, while specific aliases are not mentioned in the provided references, seems to be involved in various biological processes. It may be associated with pathways related to immune response, as an intergenic variant near it might regulate several immune-related genes [5]. Also, its potential role in diseases like periodontitis, osteoarthritis, and cancer (colorectal, kidney renal clear cell carcinoma) suggests its importance in disease-related biological mechanisms [2,3,4,6].
In research, homozygous likely deleterious variants in Leng8 were identified in patients with compatible phenotypes, indicating its possible role in Mendelian phenotypes [1]. In a study on colorectal cancer, a lncRNA related to Leng8 (LENG8-AS1) was part of a signature model for prognosis prediction [2]. In osteoarthritis patients with obesity, Leng8 was identified as a hub gene, with IPA results showing enrichment in antimicrobial, inflammatory, and humoral immune responses [3]. In a periodontitis study, Leng8 was among genes identified with shared mutations in multiple cases, suggesting it as a potential susceptibility gene [4].
In conclusion, Leng8 appears to play a role in multiple disease-related biological processes, especially those related to immune response and disease susceptibility. Findings from studies on patients with different diseases, such as those with Mendelian phenotypes, colorectal cancer, osteoarthritis with obesity, and periodontitis, have contributed to understanding the function of Leng8. These insights may provide a basis for further research into disease mechanisms and potential therapeutic targets.
References:
1. Maddirevula, Sateesh, Alzahrani, Fatema, Al-Owain, Mohammed, Monies, Dorota, Alkuraya, Fowzan S. 2018. Autozygome and high throughput confirmation of disease genes candidacy. In Genetics in medicine : official journal of the American College of Medical Genetics, 21, 736-742. doi:10.1038/s41436-018-0138-x. https://pubmed.ncbi.nlm.nih.gov/30237576/
2. Pang, Lin, Wang, Qingqing, Wang, Lingxiao, Wang, Zhenqi, Li, Yaoping. 2023. Development and validation of cuproptosis-related lncRNA signatures for prognosis prediction in colorectal cancer. In BMC medical genomics, 16, 58. doi:10.1186/s12920-023-01487-x. https://pubmed.ncbi.nlm.nih.gov/36949429/
3. Zhou, Quan, Sun, Huan, Jia, Jin, Wu, Zhao-Xiang, Chen, Zhong. 2022. Identification of Key Genes Related to the Obesity Patients with Osteoarthritis Based on Weighted Gene Coexpression Network Analysis (WGCNA). In Computational and mathematical methods in medicine, 2022, 8953807. doi:10.1155/2022/8953807. https://pubmed.ncbi.nlm.nih.gov/35860189/
4. Xue, Fan, Zhao, Jianjiang, Gao, XiaoCui, Jiang, Xuehai, Lan, Zedong. 2024. Potential susceptibility genes in patients with stage III and IV periodontitis: A whole-exome sequencing pilot study. In Biomolecules & biomedicine, 24, 73-81. doi:10.17305/bb.2023.9282. https://pubmed.ncbi.nlm.nih.gov/37435641/
5. Farias, Ticiana Della Justina, Augusto, Danillo G, de Almeida, Rodrigo Coutinho, Malheiros, Danielle, Petzl-Erler, Maria Luiza. 2018. Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation. In Immunology, 156, 86-93. doi:10.1111/imm.13003. https://pubmed.ncbi.nlm.nih.gov/30216441/
6. Song, Jukun, Liu, Yong Da, Su, Jiaming, Sun, Fa, Zhu, Jianguo. 2019. Systematic analysis of alternative splicing signature unveils prognostic predictor for kidney renal clear cell carcinoma. In Journal of cellular physiology, 234, 22753-22764. doi:10.1002/jcp.28840. https://pubmed.ncbi.nlm.nih.gov/31140607/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen