Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Tmem185aem1flox/Cya
Common Name:
Tmem185a-flox
Product ID:
S-CKO-07892
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tmem185a-flox
Strain ID
CKOCMP-236848-Tmem185a-B6J-VA
Gene Name
Tmem185a
Product ID
S-CKO-07892
Gene Alias
ee3
Background
C57BL/6JCya
NCBI ID
236848
Modification
Conditional knockout
Chromosome
X
Phenotype
MGI:2448555
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tmem185aem1flox/Cya mice (Catalog S-CKO-07892) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114630
NCBI RefSeq
NM_001357750
Target Region
Exon 3
Size of Effective Region
~1.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Tmem185a, a gene with its specific functions yet to be fully elaborated in a comprehensive manner. Based on current knowledge, it may be involved in various biological processes as its copy number can be affected by genomic rearrangements, like in a case of a complex rearrangement causing severe hemophilia A where TMEM185A was duplicated along with other genes, though its biological effect in this context did not seem dosage-dependent [3].

In cancer research, TMEM185A was identified as one of the neoantigens specifically present in lymph-node-positive breast cancers, making it a potential target for vaccine design [1]. In urinary bladder cancer, it was part of a four-gene signature (along with TMPRSS11E, SCEL, KRT78) that could predict overall survival, and this four-gene risk score had potential clinical implications in selecting high-risk patients for aggressive therapy [2]. In stage III serous ovarian carcinoma, TMEM185A was among the down-regulated genes identified by an annealing control primer system, and these differentially expressed genes might help predict patient prognosis and suggest new treatment targets [4].

In conclusion, TMEM185A shows potential significance in cancer-related biological processes, especially in breast, urinary bladder, and ovarian cancers. Its identification as a neoantigen and part of gene signatures in different cancers highlights its potential as a therapeutic target and prognostic marker, although more in-depth functional studies, potentially using gene knockout (KO) or conditional knockout (CKO) mouse models, are needed to fully understand its role in these disease conditions.

References:
1. Wang, Zhigang, Liu, Wei, Chen, Chong, Luo, Yunping, Zhang, Bailin. 2019. Low mutation and neoantigen burden and fewer effector tumor infiltrating lymphocytes correlate with breast cancer metastasization to lymph nodes. In Scientific reports, 9, 253. doi:10.1038/s41598-018-36319-x. https://pubmed.ncbi.nlm.nih.gov/30670769/
2. Chen, Siteng, Zhang, Ning, Shao, Jialiang, Wang, Tao, Wang, Xiang. 2019. A novel gene signature combination improves the prediction of overall survival in urinary bladder cancer. In Journal of Cancer, 10, 5744-5753. doi:10.7150/jca.30307. https://pubmed.ncbi.nlm.nih.gov/31737111/
3. Sheen, Campbell R, Jewell, Ursula R, Morris, Christine M, Smith, Mark P, Chen, Jian-Min. . Double complex mutations involving F8 and FUNDC2 caused by distinct break-induced replication. In Human mutation, 28, 1198-206. doi:. https://pubmed.ncbi.nlm.nih.gov/17683067/
4. Kim, Yun-Sook, Hwan, Jin Do, Bae, Sumi, Bae, Dong-Han, Shick, Woong Ahn. 2010. Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma. In BMC cancer, 10, 576. doi:10.1186/1471-2407-10-576. https://pubmed.ncbi.nlm.nih.gov/20969748/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest