Glra2, encoding the glycine receptor α2 subunit, is involved in inhibitory neurotransmission in the adult nervous system and has an excitatory action in immature neurons [2]. It is also associated with multiple biological processes and pathways, and its study in genetic models like mouse models provides insights into its functions.

In gene knockout studies, Glra2 knockout mice showed myopia-related phenotypes, decreased electroretinogram responses, and impaired retinal rod cell genesis, indicating its role in high myopia [1]. Also, Glra2 knockout mice exhibited deficits in object recognition memory and impaired long-term potentiation in the prefrontal cortex, suggesting its implication in non-syndromic autism [2]. Mice lacking the GlyR α2 subunit (encoded by Glra2) showed altered ethanol consumption and sedation, providing evidence that GlyRs are relevant targets for ethanol's sedative and rewarding properties [3].

In conclusion, Glra2 is crucial for normal nervous system function, with its role extending to processes such as vision, learning and memory, and response to ethanol. The use of Glra2 knockout mouse models has significantly contributed to understanding its functions in diseases like high myopia and non-syndromic autism, providing valuable insights into the underlying pathophysiological mechanisms.