C57BL/6JCya-Cdk17em1flox/Cya
Common Name:
Cdk17-flox
Product ID:
S-CKO-07930
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Cdk17-flox
Strain ID
CKOCMP-237459-Cdk17-B6J-VA
Gene Name
Product ID
S-CKO-07930
Gene Alias
6430598J10Rik; Pctk2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cdk17em1flox/Cya mice (Catalog S-CKO-07930) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000069965
NCBI RefSeq
NM_146239
Target Region
Exon 4
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Cdk17, also known as PCTAIRE-2, belongs to the PCTAIRE subfamily of cyclin-dependent kinases (CDKs). Although the full-scope of its functions is still being explored, kinases in this family are generally involved in cell signaling pathways, which are fundamental for normal cellular function. Dysregulation of such kinases can lead to various pathological conditions, highlighting the importance of understanding Cdk17's role [2].
In the context of liver fibrosis, miR-199a-3p was found to alleviate thioacetamide-induced liver fibrosis in a mouse model by directly downregulating Cdk17. Depletion of Cdk17 alone in activated hepatic stellate cells (HSCs) suppressed their activation, function, proliferation, and viability, mirroring the effects of miR-199a mimic treatment. This indicates that Cdk17 plays a role in promoting the activation and function of HSCs, which are central drivers of liver fibrosis [1].
In glioma research, through bioinformatics analysis of gene expression profiles, Cdk17 was identified as one of the key genes, suggesting it may play important roles in glioma prognosis and treatment, though the exact mechanisms remain to be further explored [3].
In conclusion, Cdk17 appears to be involved in multiple biological processes and disease conditions. The findings from liver fibrosis and glioma studies suggest its potential as a therapeutic target. Model-based research, such as the mouse model in liver fibrosis, has been crucial in uncovering these functions, contributing to our understanding of its role in specific disease areas.
References:
1. Choi, Min-Seok, Hong, Jae-Sang, Lee, Do-Hoon, Lee, Young Sik. 2024. MicroRNA miR-199a-3p alleviates liver fibrosis by targeting CDK17 in activated hepatic stellate cells. In Biochemical and biophysical research communications, 733, 150727. doi:10.1016/j.bbrc.2024.150727. https://pubmed.ncbi.nlm.nih.gov/39321487/
2. Karimbayli, Javad, Pellarin, Ilenia, Belletti, Barbara, Baldassarre, Gustavo. 2024. Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs. In Molecular cancer, 23, 135. doi:10.1186/s12943-024-02043-6. https://pubmed.ncbi.nlm.nih.gov/38951876/
3. Liu, Mingfa, Xu, Zhennan, Du, Zepeng, Li, Enmin, Xu, Haixiong. 2017. The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis. In Journal of immunology research, 2017, 1278081. doi:10.1155/2017/1278081. https://pubmed.ncbi.nlm.nih.gov/29362722/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen