C57BL/6JCya-Pfasem1flox/Cya
Common Name:
Pfas-flox
Product ID:
S-CKO-07954
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Pfas-flox
Strain ID
CKOCMP-237823-Pfas-B6J-VA
Gene Name
Product ID
S-CKO-07954
Gene Alias
4432409B16Rik; FGAMS; FGAR-AT; FGARAT; Gm18; PURL; Sofa
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pfasem1flox/Cya mice (Catalog S-CKO-07954) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021282
NCBI RefSeq
NM_001159519
Target Region
Exon 4~9
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
PFAS, or per-and polyfluoroalkyl substances, are not genes but a class of synthetic chemicals. They are known as "forever chemicals" due to their high persistence. PFAS are widespread in the environment, found in drinking water, foods, food packaging, and consumer products [2,3,4,5,6]. They have various industrial applications like in firefighting foams and electroplating [6]. Their presence is of concern due to potential impacts on human and environmental health.
From the references, PFAS exposure has been associated with multiple health issues. Epidemiologic studies suggest an association between PFAS and testicular, kidney, and potentially prostate cancer [1]. In the ovarian system, PFAS may disrupt ovarian function, as seen in human and toxicological studies [2]. In the brain, PFAS can enter, accumulate, and potentially lead to behavioral and cognitive disorders [3].
In conclusion, PFAS, while not a gene, are significant environmental contaminants with potential health implications. Epidemiologic and experimental studies have revealed associations with cancer, ovarian and neurological disorders. Understanding their impacts is crucial for public health and environmental protection.
References：
1. Steenland, Kyle, Winquist, Andrea. 2020. PFAS and cancer, a scoping review of the epidemiologic evidence. In Environmental research, 194, 110690. doi:10.1016/j.envres.2020.110690. https://pubmed.ncbi.nlm.nih.gov/33385391/
2. Ding, Ning, Harlow, Siobán D, Randolph, John F, Loch-Caruso, Rita, Park, Sung Kyun. . Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary. In Human reproduction update, 26, 724-752. doi:10.1093/humupd/dmaa018. https://pubmed.ncbi.nlm.nih.gov/32476019/
3. Cao, Yuexin, Ng, Carla. 2021. Absorption, distribution, and toxicity of per- and polyfluoroalkyl substances (PFAS) in the brain: a review. In Environmental science. Processes & impacts, 23, 1623-1640. doi:10.1039/d1em00228g. https://pubmed.ncbi.nlm.nih.gov/34533150/
4. Faust, Jennifer A. 2023. PFAS on atmospheric aerosol particles: a review. In Environmental science. Processes & impacts, 25, 133-150. doi:10.1039/d2em00002d. https://pubmed.ncbi.nlm.nih.gov/35416231/
5. Evangelou, Michael W H, Robinson, Brett H. 2022. The Phytomanagement of PFAS-Contaminated Land. In International journal of environmental research and public health, 19, . doi:10.3390/ijerph19116817. https://pubmed.ncbi.nlm.nih.gov/35682401/
6. Glüge, Juliane, Scheringer, Martin, Cousins, Ian T, Trier, Xenia, Wang, Zhanyun. 2020. An overview of the uses of per- and polyfluoroalkyl substances (PFAS). In Environmental science. Processes & impacts, 22, 2345-2373. doi:10.1039/d0em00291g. https://pubmed.ncbi.nlm.nih.gov/33125022/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen