C57BL/6NCya-Rxfp3em1flox/Cya
Common Name
Rxfp3-flox
Product ID
S-CKO-08113
Backgroud
C57BL/6NCya
Strain ID
CKOCMP-239336-Rxfp3-B6N-VA
Status
When using this mouse strain in a publication, please cite “Rxfp3-flox Mouse (Catalog S-CKO-08113) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Rxfp3-flox
Strain ID
CKOCMP-239336-Rxfp3-B6N-VA
Gene Name
Product ID
S-CKO-08113
Gene Alias
Salpr, Rln3r1, GPCR135
Background
C57BL/6NCya
Gene Full Name
relaxin family peptide receptor 3
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 15 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000058007
NCBI Transcript ID
NM_178717
Target Region
Exon 1
Size of Effective Region
~1.4 kb
Overview of Gene Research
Rxfp3, the relaxin-family peptide receptor 3, is a G -protein-coupled receptor. It is a key component of the relaxin-3/RXFP3 system which belongs to the relaxin/insulin superfamily. This system is involved in multiple important physiological processes such as stress responses, appetite control, motivation for reward, and also has a role in modulating neuroendocrine function related to stress, feeding, and metabolism [2,4]. It may also be associated with DNA damage response and repair processes, as its expression is affected by DNA damage and oxidative stress [1,5].
Studies in rats have shown that the RXFP3-selective negative allosteric modulator RLX-33 reduces alcohol self-administration, suggesting a role for RXFP3 in alcohol use disorder treatment [3]. Additionally, overexpression or stimulation of RXFP3 by its endogenous ligand relaxin 3 (RLN3) can regulate the DNA damage response and repair processes, and RLN3 has been linked to multiple aging-related disease processes [1]. Analyses in GIT2KO mice demonstrated that GIT2 expression affects RXFP3, indicating a therapeutically-targetable system related to metabolic aging processes [5].
In conclusion, Rxfp3 is involved in a wide range of biological functions, from physiological regulation like stress and appetite control to playing a role in aging-related diseases and potentially in alcohol use disorder. The use of animal models, such as GIT2KO mice and rats treated with RXFP3 modulators, has been crucial in uncovering these functions and highlighting the potential of Rxfp3 as a therapeutic target in related disease areas.
References：
1. Leysen, Hanne, Walter, Deborah, Clauwaert, Lore, Martin, Bronwen, Maudsley, Stuart. 2022. The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease. In International journal of molecular sciences, 23, . doi:10.3390/ijms23084387. https://pubmed.ncbi.nlm.nih.gov/35457203/
2. Rahman, Md Toufiqur, Chaminda Lakmal, Hetti Handi, Hussain, Javeena, Jin, Chunyang. 2024. Targeting the relaxin-3/RXFP3 system: a patent review for the last two decades. In Expert opinion on therapeutic patents, 34, 71-81. doi:10.1080/13543776.2024.2338099. https://pubmed.ncbi.nlm.nih.gov/38573177/
3. Van Voorhies, Kalynn J, Liu, Wen, Lovelock, Dennis F, Jin, Chunyang, Besheer, Joyce. 2023. Novel RXFP3 negative allosteric modulator RLX-33 reduces alcohol self-administration in rats. In Journal of neurochemistry, 167, 204-217. doi:10.1111/jnc.15949. https://pubmed.ncbi.nlm.nih.gov/37674350/
4. Ganella, Despina E, Ma, Sherie, Gundlach, Andrew L. 2013. Relaxin-3/RXFP3 Signaling and Neuroendocrine Function - A Perspective on Extrinsic Hypothalamic Control. In Frontiers in endocrinology, 4, 128. doi:10.3389/fendo.2013.00128. https://pubmed.ncbi.nlm.nih.gov/24065955/
5. van Gastel, Jaana, Leysen, Hanne, Santos-Otte, Paula, Martin, Bronwen, Maudsley, Stuart. 2019. The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage. In Aging, 11, 11268-11313. doi:10.18632/aging.102528. https://pubmed.ncbi.nlm.nih.gov/31794429/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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