C57BL/6JCya-Slc2a13em1flox/Cya
Common Name:
Slc2a13-flox
Product ID:
S-CKO-08152
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc2a13-flox
Strain ID
CKOCMP-239606-Slc2a13-B6J-VA
Gene Name
Product ID
S-CKO-08152
Gene Alias
6530403A04; A630029G22Rik; Gm308
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc2a13em1flox/Cya mice (Catalog S-CKO-08152) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000109283
NCBI RefSeq
NM_001033633
Target Region
Exon 2
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Slc2a13, also known as the proton myo-inositol cotransporter, is a member of the solute carrier family 2. It plays a role in the transportation of myo-inositol along with protons across cell membranes. It is associated with the γ-secretase complex, and thus is involved in the processing of amyloid precursor protein, which is related to the pathogenesis of Alzheimer's disease. Additionally, as a solute carrier, it may be related to nutrient transport and metabolism-related pathways in cells [1].
In Alzheimer's disease research, silencing of Slc2a13 led to a clear reduction of amyloid β-peptide (Aβ) secretion in a small interfering RNA dose-dependent manner. Overexpression of Slc2a13 increased Aβ40 generation. Also, the interaction between γ-secretase and Slc2a13 was confirmed, suggesting it could be a target for Aβ-lowering therapy [1].
In acute myeloid leukemia (AML), patients with high Slc2a13 expression exhibited a better prognosis, indicating its potential as a prognostic biomarker [2].
In oral squamous cell carcinoma, Slc2a13 was identified as a potential marker for cancer stem cells as it was over-expressed in sphere-forming cells which are enriched with potential CSCs [3].
In Parkinson's disease, genetic association studies showed that there is a caffeine-gene interaction involving Slc2a13 which may influence the risk of PD, and a 5-copy GGGAAA repeat in Slc2a13 was significantly associated with PD [4,5].
In conclusion, Slc2a13 has diverse functions in different biological processes and disease conditions. Its role in regulating Aβ production in Alzheimer's disease, as a prognostic biomarker in AML, as a potential cancer stem cell marker, and in the gene-caffeine interaction in Parkinson's disease, is of great significance. Functional studies, especially those using gene knockout or conditional knockout mouse models in the future, may further clarify its molecular mechanisms in these diseases.
References:
1. Teranishi, Yasuhiro, Inoue, Mitsuhiro, Yamamoto, Natsuko Goto, Frykman, Susanne, Tjernberg, Lars O. 2015. Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage. In The FEBS journal, 282, 3438-51. doi:10.1111/febs.13353. https://pubmed.ncbi.nlm.nih.gov/26094765/
2. Lai, Binbin, Lai, Yanli, Zhang, Yanli, Sheng, Lixia, OuYang, Guifang. . The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia. In Technology in cancer research & treatment, 19, 1533033819894308. doi:10.1177/1533033819894308. https://pubmed.ncbi.nlm.nih.gov/31918632/
3. Lee, D G, Lee, J-H, Choi, B K, Bae, Y-S, Kwon, B S. . H⁺-myo-inositol transporter SLC2A13 as a potential marker for cancer stem cells in an oral squamous cell carcinoma. In Current cancer drug targets, 11, 966-75. doi:. https://pubmed.ncbi.nlm.nih.gov/21861841/
4. Yang, Yujuan, Zhou, Zhi Dong, Yi, Lingxiao, Tan, Brendan Jen-Wei, Tan, Eng-King. 2024. Interaction between caffeine consumption & genetic susceptibility in Parkinson's disease: A systematic review. In Ageing research reviews, 99, 102381. doi:10.1016/j.arr.2024.102381. https://pubmed.ncbi.nlm.nih.gov/38914264/
5. Wang, Chaodong, Liu, Hankui, Li, Xu-Ying, Zhang, Jianguo, Chan, Piu. 2024. High-depth whole-genome sequencing identifies structure variants, copy number variants and short tandem repeats associated with Parkinson's disease. In NPJ Parkinson's disease, 10, 134. doi:10.1038/s41531-024-00722-1. https://pubmed.ncbi.nlm.nih.gov/39043730/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen