C57BL/6JCya-Mrgpreem1flox/Cya
Common Name
Mrgpre-flox
Product ID
S-CKO-08590
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-244238-Mrgpre-B6J-VA
Status
When using this mouse strain in a publication, please cite “Mrgpre-flox Mouse (Catalog S-CKO-08590) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Mrgpre-flox
Strain ID
CKOCMP-244238-Mrgpre-B6J-VA
Gene Name
Product ID
S-CKO-08590
Gene Alias
Mgrf, MrgE, Ebrt3, C130069N09Rik
Background
C57BL/6JCya
Gene Full Name
MAS-related GPR, member E
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 7 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000054048
NCBI Transcript ID
NM_175534
Target Region
Exon 2
Size of Effective Region
~1.4 kb
Overview of Gene Research
Mrgpre, short for MAS related GPR family member E, has been implicated in various biological processes. It may be involved in pain-associated pathways as it was identified as a target gene of miR-143-3p which is related to the regulation of pain responses in collagen-induced arthritis. In this context, its expression was significantly upregulated in the dorsal root ganglion of CIA mice, suggesting its role in chronic inflammatory and neuropathic pain [3].
Mrgpre has also been associated with several other health-related conditions. It was identified as one of the 21 druggable genes significantly associated with migraine, indicating its potential as a therapeutic target for migraine treatment [1]. Additionally, DNA methylation sites related to Mrgpre were found to be associated with waist circumference in Chinese monozygotic twins, BMI-related DNA methylation variation in Chinese monozygotic twins, and lung function in Latino children and youth with asthma [2,4,5].
In conclusion, Mrgpre appears to be involved in multiple biological processes related to pain, migraine, obesity-related traits, and lung function. Its identification in these contexts through various genetic association studies provides valuable insights into potential disease mechanisms and possible therapeutic targets, especially in migraine treatment.
References：
1. Zhang, Chengcheng, He, Yiwei, Liu, Lu. 2024. Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization. In The journal of headache and pain, 25, 100. doi:10.1186/s10194-024-01805-3. https://pubmed.ncbi.nlm.nih.gov/38867170/
2. Xing, Fangjie, Han, Fulei, Wu, Yan, Zhang, Dongfeng, Wu, Yili. 2024. An epigenome-wide association study of waist circumference in Chinese monozygotic twins. In International journal of obesity (2005), 48, 1148-1156. doi:10.1038/s41366-024-01538-y. https://pubmed.ncbi.nlm.nih.gov/38773251/
3. Zhou, Ling-Ling, Zhu, Ya-Mei, Qian, Fei-Ya, Yuan, Dong-Ping, Zhou, Xue-Ping. 2018. MicroRNA‑143‑3p contributes to the regulation of pain responses in collagen‑induced arthritis. In Molecular medicine reports, 18, 3219-3228. doi:10.3892/mmr.2018.9322. https://pubmed.ncbi.nlm.nih.gov/30066874/
4. Herrera-Luis, Esther, Li, Annie, Mak, Angel C Y, Burchard, Esteban G, Pino-Yanes, Maria. 2022. Epigenome-wide association study of lung function in Latino children and youth with asthma. In Clinical epigenetics, 14, 9. doi:10.1186/s13148-022-01227-5. https://pubmed.ncbi.nlm.nih.gov/35033200/
5. Wang, Weijing, Li, Weilong, Duan, Haiping, Tan, Qihua, Zhang, Dongfeng. 2022. Mediation by DNA methylation on the association of BMI and serum uric acid in Chinese monozygotic twins. In Gene, 850, 146957. doi:10.1016/j.gene.2022.146957. https://pubmed.ncbi.nlm.nih.gov/36243213/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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