Or5v1, an olfactory receptor gene, is part of a large family of genes involved in the sense of smell. Olfactory receptors play a crucial role in detecting and transducing odorant signals, which are essential for various physiological and behavioral processes related to olfaction [2,3,4]. Genetic models can be used to study Or5v1 to understand its precise function and its role in related biological pathways.

Multiple variations in Or5v1 were found to be associated with autism spectrum disorder (ASD) in Saudi females, suggesting that these genetic changes may contribute to the development of ASD in this population [1]. Additionally, Or5v1 was among the genes with risk variants recessively associated with high triglycerides (TGs) in an Arab population, indicating its possible involvement in lipid-related processes [2]. A genome-wide association on an accelerated aging phenotype identified single nucleotide polymorphisms near Or5v1, suggesting a potential link between this gene and accelerated aging [3]. In a study on inflammatory bowel disease (IBD), Or5v1 was among several genes with associations that were replicated in at least one independent sample, pointing to its possible involvement in IBD [4].

In conclusion, Or5v1 is an olfactory receptor gene with potential implications in multiple disease areas such as ASD, high TGs, accelerated aging, and IBD. Research using genetic models can further elucidate its biological functions and how its variations contribute to these disease conditions.