C57BL/6JCya-Or10p1em1flox/Cya
Common Name:
Or10p1-flox
Product ID:
S-CKO-09363
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Or10p1-flox
Strain ID
CKOCMP-258933-Or10p1-B6J-VA
Gene Name
Product ID
S-CKO-09363
Gene Alias
MOR269-1; Olfr796
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Or10p1em1flox/Cya mice (Catalog S-CKO-09363) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000037071
NCBI RefSeq
NM_146931
Target Region
Exon 1
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Or10p1, also known as OLFR796 in mice, is a receptor gene. It is involved in the famsin-glucagon axis which mediates glucose homeostasis. Famsin, a gut-secreted hormone, binds to OR10P1, initiating calcium release in islet α cells' endoplasmic reticulum, triggering glucagon secretion and promoting hepatic glucose production [1].
In a genome-wide association study, SNP rs17117817 near OR10P1 was associated with heart rate response to β-blockers in both blacks and whites, highlighting OR10P1 as a novel gene related to heart rate changes in response to β-blockers [2]. Also, in Italian beef cattle breeds, OR10P1 was located in a breed-specific genomic region identified through ROH analysis, suggesting its potential selective and conservative interest in cattle genetics [3].
In conclusion, Or10p1 plays a crucial role in glucose homeostasis via the famsin-glucagon axis. Its association with heart rate response to β-blockers and presence in specific genomic regions of cattle imply its importance in multiple biological contexts. Research on Or10p1, including potential KO/CKO mouse models, could further clarify its functions and implications in related diseases and genetic traits.
References：
1. Long, Aijun, Wang, Yazhuo, Guo, Yihua, Wang, Jiqiu, Wang, Yiguo. 2024. A famsin-glucagon axis mediates glucose homeostasis. In Cell metabolism, 37, 629-639.e6. doi:10.1016/j.cmet.2024.11.008. https://pubmed.ncbi.nlm.nih.gov/39706194/
2. Shahin, Mohamed H, Conrado, Daniela J, Gonzalez, Daniel, Cooper-DeHoff, Rhonda M, Johnson, Julie A. 2018. Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers. In Journal of the American Heart Association, 7, . doi:10.1161/JAHA.117.006463. https://pubmed.ncbi.nlm.nih.gov/29478026/
3. Fabbri, Maria Chiara, Dadousis, Christos, Tiezzi, Francesco, Biffani, Stefano, Bozzi, Riccardo. 2021. Genetic diversity and population history of eight Italian beef cattle breeds using measures of autozygosity. In PloS one, 16, e0248087. doi:10.1371/journal.pone.0248087. https://pubmed.ncbi.nlm.nih.gov/34695128/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen