C57BL/6JCya-Axlem1flox/Cya
Common Name
Axl-flox
Product ID
S-CKO-09532
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-26362-Axl-B6J-VA
Status
When using this mouse strain in a publication, please cite “Axl-flox Mouse (Catalog S-CKO-09532) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Axl-flox
Strain ID
CKOCMP-26362-Axl-B6J-VA
Gene Name
Product ID
S-CKO-09532
Gene Alias
Ark, Ufo, Tyro7
Background
C57BL/6JCya
Gene Full Name
AXL receptor tyrosine kinase
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 7 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000002677
NCBI Transcript ID
NM_009465
Target Region
Exon 5~6
Size of Effective Region
~1.4 kb
Overview of Gene Research
Axl, a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases family, binds to its high-affinity ligand growth arrest specific 6 (Gas6), and the Gas6/Axl signaling pathway is implicated in multiple biological processes [1-3]. It plays a crucial role in cancer development, progression, metastasis, immune evasion, and drug resistance. In addition, Axl is emerging as an important regulator of neuroendocrine development and function in the hypothalamic-pituitary-gonadal axis [3].
In cancer, numerous studies have shown that Axl is involved in pro-tumorigenic processes such as cell migration, invasion, epithelial-mesenchymal transition (EMT), and stemness [4]. Reducing Axl expression can weaken cancer cells' drug resistance, indicating its potential as a target for anti-cancer drug treatment [1]. Axl also drives anti-HER2 resistance and metastasis in breast cancer through dimerization with HER2 and activation of downstream pathways, and its inhibition can restore response to HER2 blockade [2]. In NSCLC, Axl is associated with the emergence of resistance to tyrosine kinase inhibitors (TKIs) and chemotherapeutics [5].
In conclusion, Axl is a key molecule involved in both cancer-related and neuroendocrine-related biological processes. The role of Axl in promoting cancer progression and drug resistance has been well-demonstrated through various in vivo and in vitro studies. Targeting Axl, either alone or in combination with other therapies, shows promise in improving cancer treatment outcomes, especially in cancers like breast cancer and NSCLC where Axl-mediated resistance is a significant issue.
References：
1. Tang, Yaoxiang, Zang, Hongjing, Wen, Qiuyuan, Fan, Songqing. 2023. AXL in cancer: a modulator of drug resistance and therapeutic target. In Journal of experimental & clinical cancer research : CR, 42, 148. doi:10.1186/s13046-023-02726-w. https://pubmed.ncbi.nlm.nih.gov/37328828/
2. Adam-Artigues, Anna, Arenas, Enrique J, Arribas, Joaquín, Prat, Aleix, Cejalvo, Juan Miguel. 2023. AXL - a new player in resistance to HER2 blockade. In Cancer treatment reviews, 121, 102639. doi:10.1016/j.ctrv.2023.102639. https://pubmed.ncbi.nlm.nih.gov/37864955/
3. Mohammadzadeh, Pardis, Amberg, Gregory C. 2023. AXL/Gas6 signaling mechanisms in the hypothalamic-pituitary-gonadal axis. In Frontiers in endocrinology, 14, 1212104. doi:10.3389/fendo.2023.1212104. https://pubmed.ncbi.nlm.nih.gov/37396176/
4. Khera, Lohit, Lev, Sima. 2021. Accelerating AXL targeting for TNBC therapy. In The international journal of biochemistry & cell biology, 139, 106057. doi:10.1016/j.biocel.2021.106057. https://pubmed.ncbi.nlm.nih.gov/34403827/
5. Zaman, Aubhishek, Bivona, Trever G. 2021. Targeting AXL in NSCLC. In Lung Cancer (Auckland, N.Z.), 12, 67-79. doi:10.2147/LCTT.S305484. https://pubmed.ncbi.nlm.nih.gov/34408519/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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