C57BL/6JCya-Tafa2em1flox/Cya
Common Name
Tafa2-flox
Product ID
S-CKO-09650
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-268354-Tafa2-B6J-VA
When using this mouse strain in a publication, please cite “Tafa2-flox Mouse (Catalog S-CKO-09650) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tafa2-flox
Strain ID
CKOCMP-268354-Tafa2-B6J-VA
Gene Name
Product ID
S-CKO-09650
Gene Alias
Sam2, Tafa-2, Fam19a2, 6330575M02, FAM19A2 TAFA-2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000050756
NCBI RefSeq
NM_182807
Target Region
Exon 4~5
Size of Effective Region
~2.2 kb
Overview of Gene Research
TAFA2, also known as FAM19A2, is a cytokine specifically expressed in the central nervous system. It plays a vital role in multiple biological processes. In neurons, it functions as a neurotrophic factor essential for neuronal survival. It activates the cAMP/PKA/CREB/BCL2 signaling pathway by binding to ADGRL1 to suppress apoptosis [2]. In skeletal (stromal) stem cells, TAFA2 induces their migration through the activation of the Rac1-p38 signaling pathway, which is relevant for regenerative medicine applications [1].
Tafa-2 knockout mice were generated to investigate its in vivo function. The mutant mice showed impairments in spatial learning, memory, and abnormal anxiety-and depression-like behaviors. Further examination revealed that Tafa-2 deficiency led to severe neuronal reduction and increased apoptosis in the brain via downregulation of the PI3K/Akt and MAPK/Erk pathways [3].
In conclusion, TAFA2 is crucial for neuronal survival and neurobiological functions as demonstrated by knockout mouse models. It also has potential implications in regenerative medicine related to stem cell migration. These findings from model-based research provide insights into understanding related biological processes and possible therapeutic targets for neurological and regenerative-related diseases.
References：
1. Jafari, Abbas, Isa, Adiba, Chen, Li, Clausen, Christian, Kassem, Moustapha. 2018. TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling. In Stem cells (Dayton, Ohio), 37, 407-416. doi:10.1002/stem.2955. https://pubmed.ncbi.nlm.nih.gov/30485583/
2. Liang, Hui, Tang, Ling Yun, Ge, Hao Yang, Fei, Jian, Wang, Zhu Gang. 2023. Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway. In Life sciences, 334, 122241. doi:10.1016/j.lfs.2023.122241. https://pubmed.ncbi.nlm.nih.gov/37944639/
3. Wang, Xiyi, Shen, Chunling, Chen, Xuejiao, Fei, Jian, Wang, Zhugang. . Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice. In Acta biochimica et biophysica Sinica, 50, 984-995. doi:10.1093/abbs/gmy097. https://pubmed.ncbi.nlm.nih.gov/30137205/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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