C57BL/6JCya-Gpr152em1flox/Cya
Common Name:
Gpr152-flox
Product ID:
S-CKO-09748
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Gpr152-flox
Strain ID
CKOCMP-269053-Gpr152-B6J-VA
Gene Name
Product ID
S-CKO-09748
Gene Alias
A930009H15Rik; Gm673
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gpr152em1flox/Cya mice (Catalog S-CKO-09748) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000096338
NCBI RefSeq
NM_206973
Target Region
Exon 2
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Gpr152 is a member of the Rhodopsin family of human G protein-coupled receptors (GPCRs), and it shows an evolutionary relationship to CRTH2/FPRs [1]. GPCRs are crucial in various cellular signaling pathways, which may involve processes like cell-cell communication, regulation of physiological functions, and response to external stimuli.
In a study focused on diffuse-type gastric cancer, a single-nucleotide polymorphism (SNP) rs869736 at position-309 of the PTPRCAP promoter was associated with susceptibility to this cancer type. Nine other SNPs in nearly perfect linkage disequilibrium with this SNP spread out for 26 kb on chromosome 11q13.1 covering RPS6KB2, PTPRCAP, CORO1B, and Gpr152. However, among these four genes, only PTPRCAP expression was affected by the haplotypes of the 10 SNPs [2].
In conclusion, Gpr152, as a GPCR, is likely involved in cellular signaling pathways. Although the research mainly focused on SNPs near Gpr152 in relation to diffuse-type gastric cancer, it did not directly reveal the function of Gpr152 through gene-knockout models. Future research using KO or CKO mouse models could potentially further clarify its role in this and other disease-related biological processes.
References：
1. Gloriam, David E I, Schiöth, Helgi B, Fredriksson, Robert. . Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. In Biochimica et biophysica acta, 1722, 235-46. doi:. https://pubmed.ncbi.nlm.nih.gov/15777626/
2. Ju, Hyoungseok, Lim, Byungho, Kim, Minjin, Choi, Bo Youl, Kang, Changwon. . A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. In Neoplasia (New York, N.Y.), 11, 1340-7. doi:. https://pubmed.ncbi.nlm.nih.gov/20019842/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen