C57BL/6JCya-Lix1lem1flox/Cya
Common Name
Lix1l-flox
Product ID
S-CKO-10123
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-280411-Lix1l-B6J-VA
When using this mouse strain in a publication, please cite “Lix1l-flox Mouse (Catalog S-CKO-10123) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Lix1l-flox
Strain ID
CKOCMP-280411-Lix1l-B6J-VA
Gene Name
Product ID
S-CKO-10123
Gene Alias
D130027M04Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000062058
NCBI RefSeq
NM_001163170.1
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Overview of Gene Research
Lix1l, or Limb expression 1-like protein, is involved in post-transcriptional gene regulation. It has been associated with multiple biological processes and disease-related pathways. Genetic models, such as knockout mice, have been crucial in studying its functions [1,2,3].
Lix1l knockout mice studies revealed that Lix1l deficiency alleviates cholestatic liver injury by inhibiting bile acid synthesis, as LIX1L functions as a link between BA/Egr-1 and miR-191-3p/LRH-1 signaling [1]. Also, Lix1l deletion in mice inhibits hepatic lipid accumulation, inflammation, and fibrosis as well as adipocyte differentiation by downregulating CD36, alleviating metabolic dysfunction-associated steatohepatitis (MASH) and associated hepatocellular carcinoma (HCC) progression [2]. In addition, Lix1l deficiency in vivo significantly attenuated liver cancer initiation in mice, and LIX1L knockdown up-regulated fructose-1,6-bisphosphatase (FBP1) expression to reduce glucose consumption and lactate production [3].
In conclusion, Lix1l plays important roles in liver-related diseases including cholestatic liver injury, MASH, and HCC. Gene knockout mouse models have been instrumental in uncovering these functions, highlighting Lix1l as a potential therapeutic target for these diseases.
References：
1. Li, Jie, Zhu, Xiaoyun, Zhang, Meihui, Kong, Lingyi, Zhang, Hao. 2021. Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism. In Journal of hepatology, 75, 400-413. doi:10.1016/j.jhep.2021.02.035. https://pubmed.ncbi.nlm.nih.gov/33746084/
2. Leng, Yingrong, Zhang, Yanqiu, Cheng, Yang, Kong, Lingyi, Zhang, Hao. 2024. LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36. In Pharmacological research, 211, 107567. doi:10.1016/j.phrs.2024.107567. https://pubmed.ncbi.nlm.nih.gov/39725340/
3. Zou, Jie, Zhu, Xiaoyun, Xiang, Dejuan, Kong, Lingyi, Zhang, Hao. 2021. LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase. In Acta pharmaceutica Sinica. B, 11, 1578-1591. doi:10.1016/j.apsb.2021.02.005. https://pubmed.ncbi.nlm.nih.gov/34221869/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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