C57BL/6JCya-Mapk12em1flox/Cya
Common Name:
Mapk12-flox
Product ID:
S-CKO-10178
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mapk12-flox
Strain ID
CKOCMP-29857-Mapk12-B6J-VA
Gene Name
Product ID
S-CKO-10178
Gene Alias
Erk6; P38gamma; Prkm12; Sapk3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mapk12em1flox/Cya mice (Catalog S-CKO-10178) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000088827
NCBI RefSeq
NM_013871
Target Region
Exon 3
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Mapk12, also known as p38γ, is a member of the p38 MAPK family. It is crucial in regulating various cellular processes, including proliferation, differentiation, apoptosis, and stress responses. Mitogen-activated protein kinase (MAPK) cascades, in which Mapk12 is involved, are key signaling pathways in cancer development, and Mapk12 has been associated with the development and progression of multiple tumor types [1,3,4].
In a study generating a Mapk12D171A/D171A/Mapk13-/- (p38γ/δKIKO) mouse, which expresses kinase-inactive p38γ and lacks p38δ, researchers found that this mouse exhibited a reduced inflammatory response and less susceptibility to lipopolysaccharide (LPS)-induced septic shock and Candida albicans infection than wild-type mice. This indicates that Mapk12 may play a role in the innate immune response by regulating the phosphorylation and transcriptional activity of the transcription factor myocyte enhancer factor-2D (MEF2D) [2].
In conclusion, Mapk12 is important in regulating cellular processes and immune responses. Its role in diseases, especially in cancer development and innate immune response, has been revealed through the use of gene-modified mouse models. Understanding Mapk12 can provide insights into disease mechanisms and potential therapeutic targets.
References：
1. Wang, Jinju, Song, Zhe, Ren, Li, Gu, Yi, Feng, Chao. 2022. Pan-cancer analysis supports MAPK12 as a potential prognostic and immunotherapeutic target in multiple tumor types, including in THCA. In Oncology letters, 24, 445. doi:10.3892/ol.2022.13565. https://pubmed.ncbi.nlm.nih.gov/36420075/
2. Escós, Alejandra, Diaz-Mora, Ester, Pattison, Michael, Ley, Steven C, Cuenda, Ana. 2023. p38γ and p38δ modulate innate immune response by regulating MEF2D activation. In eLife, 12, . doi:10.7554/eLife.86200. https://pubmed.ncbi.nlm.nih.gov/37458356/
3. Phan, Thuy, Zhang, Xu Hannah, Rosen, Steven, Melstrom, Laleh G. 2023. P38 kinase in gastrointestinal cancers. In Cancer gene therapy, 30, 1181-1189. doi:10.1038/s41417-023-00622-1. https://pubmed.ncbi.nlm.nih.gov/37248432/
4. Liu, Yue, Zhang, Han, Zhao, Shu, Zhang, Yue. 2024. A retrospective analysis of the clinicopathological features and prognostic value of MAPK12 protein expression in diffuse large B-cell lymphoma. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 26, 2966-2978. doi:10.1007/s12094-024-03515-3. https://pubmed.ncbi.nlm.nih.gov/38773060/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen