C57BL/6JCya-Snai3em1flox/Cya
Common Name
Snai3-flox
Product ID
S-CKO-10224
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-30927-Snai3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Snai3-flox Mouse (Catalog S-CKO-10224) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Snai3-flox
Strain ID
CKOCMP-30927-Snai3-B6J-VA
Gene Name
Product ID
S-CKO-10224
Gene Alias
Smuc, Zfp293
Background
C57BL/6JCya
Gene Full Name
snail family zinc finger 3
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 8 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000006762
NCBI Transcript ID
NM_013914
Target Region
Exon 2~3
Size of Effective Region
~2.2 kb
Overview of Gene Research
Snai3, a member of the Snail gene family, encodes a zinc finger-containing transcriptional repressor protein. It is involved in regulating cell-lineage determination in the hematopoietic system, and may play roles in processes like folliculogenesis, luteinization, and early embryonic development [1,3]. In the hematopoietic system, it can influence the development of lymphoid and myeloid lineages. In ovarian and embryonic processes, its expression pattern suggests potential regulatory functions [1,3]. Genetic mouse models are valuable for studying Snai3's functions.
In gene knockout studies, Snai3 null mutant homozygous mice are viable and fertile, indicating that Snai3 is not essential for embryogenesis [4]. Deletion of both Snai2 and Snai3 in mice leads to impaired physical development, lymphocyte deficiency, and stunted growth, suggesting some functional redundancy or cooperation between Snai2 and Snai3 [2]. Also, Snai3 does not have a major role in regulating skeletal muscle regeneration in mice [5].
In conclusion, Snai3 is not essential for embryogenesis or skeletal muscle regeneration in mice. However, its combined deletion with Snai2 impairs physical and immune cell development. These gene knockout mouse models have provided insights into Snai3's role in development and immune-related processes, helping to understand its biological functions and potential implications in related diseases.
References：
1. Dahlem, Timothy, Cho, Scott, Spangrude, Gerald J, Weis, Janis J, Weis, John H. . Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation. In European journal of immunology, 42, 1038-43. doi:10.1002/eji.201142193. https://pubmed.ncbi.nlm.nih.gov/22531927/
2. Pioli, Peter D, Dahlem, Timothy J, Weis, Janis J, Weis, John H. 2013. Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency. In PloS one, 8, e69216. doi:10.1371/journal.pone.0069216. https://pubmed.ncbi.nlm.nih.gov/23874916/
3. Guo, Shujuan, Yan, Xingyu, Shi, Feifei, Chen, Zi-Jiang, Zhang, Cong. 2018. Expression and distribution of the zinc finger protein, SNAI3, in mouse ovaries and pre-implantation embryos. In The Journal of reproduction and development, 64, 179-186. doi:10.1262/jrd.2017-088. https://pubmed.ncbi.nlm.nih.gov/29445069/
4. Bradley, Cara K, Norton, Christine R, Chen, Ying, Krebs, Luke T, Gridley, Thomas. 2013. The snail family gene snai3 is not essential for embryogenesis in mice. In PloS one, 8, e65344. doi:10.1371/journal.pone.0065344. https://pubmed.ncbi.nlm.nih.gov/23762348/
5. Norton, Christine R, Chen, Ying, Han, Xiang Hua, Yoon, Jeong Kyo, Gridley, Thomas. 2013. Absence of a major role for the snai1 and snai3 genes in regulating skeletal muscle regeneration in mice. In PLoS currents, 5, . doi:10.1371/currents.md.e495b27ee347fd3870a8316d4786fc17. https://pubmed.ncbi.nlm.nih.gov/24270643/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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