C57BL/6JCya-Zfp182em1flox/Cya
Common Name
Zfp182-flox
Product ID
S-CKO-10302
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-319535-Zfp182-B6J-VA
When using this mouse strain in a publication, please cite “Zfp182-flox Mouse (Catalog S-CKO-10302) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Zfp182-flox
Strain ID
CKOCMP-319535-Zfp182-B6J-VA
Gene Name
Product ID
S-CKO-10302
Gene Alias
Znf182, 6330583I20Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000115333
NCBI RefSeq
NM_001013387
Target Region
Exon 3~4
Size of Effective Region
~0.9 kb
Overview of Gene Research
Zfp182, a TFIIIA-type zinc finger protein, is involved in multiple abiotic stress responses in plants. It plays a role in pathways related to abscisic acid (ABA)-induced antioxidant defense, salt, cold and drought tolerances. Understanding its function is crucial for improving stress tolerance in crops [1,2,3].
In rice, ABA treatment induces Zfp182 expression, and it is required for ABA-induced antioxidant defense as transient gene expression and RNAi analysis in protoplasts showed its involvement in up-regulating superoxide dismutase (SOD) and ascorbate peroxidase (APX) activities. Also, rice MAPKs, OsMPK1 and OsMPK5, are required for Zfp182 up-regulation in ABA signaling [1]. Overexpression of Zfp182 in transgenic rice significantly enhanced multiple abiotic stress tolerances, promoting the accumulation of compatible osmolytes and activating stress-related genes like OsP5CS, OsLEA3, OsDREB1A and OsDREB1B [2]. Expression of Zfp182 in transgenic tobacco and overexpression in rice increased plant tolerance to salt stress [3]. In wheat, mutations in NAC transcription factors affected the transcription pattern of Zfp182 under salt or drought stress [4]. In rice, a superior haplotype of Zfp182 was associated with higher single plant yield under drought stress [5].
In conclusion, Zfp182 is essential for plants' responses to various abiotic stresses, including those mediated by ABA, salt, cold and drought. Its study in plant models provides insights into stress-tolerance mechanisms, offering potential for improving crop resilience to environmental challenges.
References：
1. Zhang, Hong, Ni, Lan, Liu, Yanpei, Tan, Mingpu, Jiang, Mingyi. . The C2H2-type zinc finger protein ZFP182 is involved in abscisic acid-induced antioxidant defense in rice. In Journal of integrative plant biology, 54, 500-10. doi:10.1111/j.1744-7909.2012.01135.x. https://pubmed.ncbi.nlm.nih.gov/22693960/
2. Huang, Ji, Sun, Shujing, Xu, Dongqing, Tang, Haijuan, Zhang, Hongsheng. 2012. A TFIIIA-type zinc finger protein confers multiple abiotic stress tolerances in transgenic rice (Oryza sativa L.). In Plant molecular biology, 80, 337-50. doi:10.1007/s11103-012-9955-5. https://pubmed.ncbi.nlm.nih.gov/22930448/
3. Huang, Ji, Yang, Xia, Wang, Mei-Mei, Shen, Yin, Zhang, Hong-Sheng. 2007. A novel rice C2H2-type zinc finger protein lacking DLN-box/EAR-motif plays a role in salt tolerance. In Biochimica et biophysica acta, 1769, 220-7. doi:. https://pubmed.ncbi.nlm.nih.gov/17434609/
4. Wang, Dongzhi, Li, Yongpeng, Wang, Haojie, Liu, Xigang, Xiao, Jun. 2023. Boosting wheat functional genomics via an indexed EMS mutant library of KN9204. In Plant communications, 4, 100593. doi:10.1016/j.xplc.2023.100593. https://pubmed.ncbi.nlm.nih.gov/36945776/
5. Singh, Preeti, Sundaram, Krishna T, Vinukonda, Vishnu Prasanth, Singh, Vikas K, Sinha, Pallavi. 2024. Superior haplotypes of key drought-responsive genes reveal opportunities for the development of climate-resilient rice varieties. In Communications biology, 7, 89. doi:10.1038/s42003-024-05769-7. https://pubmed.ncbi.nlm.nih.gov/38216712/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.