C57BL/6JCya-Olfml2bem1flox/Cya
Common Name
Olfml2b-flox
Product ID
S-CKO-10382
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-320078-Olfml2b-B6J-VA
When using this mouse strain in a publication, please cite “Olfml2b-flox Mouse (Catalog S-CKO-10382) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Olfml2b-flox
Strain ID
CKOCMP-320078-Olfml2b-B6J-VA
Gene Name
Product ID
S-CKO-10382
Gene Alias
1110018N05Rik, 4832415H08Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000046792
NCBI RefSeq
NM_177068
Target Region
Exon 5
Size of Effective Region
~0.7 kb
Overview of Gene Research
Olfml2b, a member of the olfactomedin domain-containing protein family, has an ambiguous function, especially in tumors. Its role in biological processes may involve cell growth, cell cycle regulation, apoptosis, and cell communication through pathways like the M/G1 transition pathway, post-translational protein modification, and DNA replication pre-initiation [3].
Genome-wide screening identified Olfml2b as a robust prognostic biomarker in bladder cancer. High expression of Olfml2b was associated with poor prognosis, and its expression increased with the rise of stage and grade. Knockdown of Olfml2b in bladder cancer cell lines led to decreased migration and proliferation ability [1]. Pan-cancer analysis showed that Olfml2b was overexpressed in 14 cancers and related to prognosis, TMB, MSI, TME, and immune cell infiltration. It may also increase drug resistance of certain drugs [2].
In gastric cancer, Olfml2b was overexpressed, associated with tumor invasion depth and clinical stage, and could be used as a diagnostic and prognostic target [3]. In stomach adenocarcinoma, Olfml2b was among the genes associated with overall survival and related to immune cell fractions [4]. In gastric cancer, it was also identified as a hub gene for prognosis prediction [5].
In triple-negative breast cancer, Olfml2b was one of the genes influencing prognosis [6]. In ovarian cancer, Olfml2b was selected as a prognostic gene for a lactate metabolism-related prognostic model [7].
In summary, Olfml2b is a potential prognostic marker and a possible target for immunotherapy in various tumors. Its overexpression in many cancers is associated with poor prognosis, and its function in promoting cancer cell migration, proliferation, and drug resistance suggests its significance in cancer development. The studies on Olfml2b contribute to understanding cancer mechanisms and developing more effective cancer treatments.
References：
1. Lin, Jiaxing, Xu, Xiao, Li, Tianren, Zhu, Yuyan, Sun, Dan. 2021. OLFML2B Is a Robust Prognostic Biomarker in Bladder Cancer Through Genome-Wide Screening: A Study Based on Seven Cohorts. In Frontiers in oncology, 11, 650678. doi:10.3389/fonc.2021.650678. https://pubmed.ncbi.nlm.nih.gov/34868901/
2. Hu, Pengbo, Zhang, Xiuyuan, Li, Yiming, Xu, Liang, Qiu, Hong. 2022. Pan-Cancer Analysis of OLFML2B Expression and Its Association With Prognosis and Immune Infiltration. In Frontiers in genetics, 13, 882794. doi:10.3389/fgene.2022.882794. https://pubmed.ncbi.nlm.nih.gov/35873458/
3. Liu, Jiaxin, Liu, Zhao, Zhang, Xiaozhi, Gong, Tuotuo, Yao, Demao. 2019. Bioinformatic exploration of OLFML2B overexpression in gastric cancer base on multiple analyzing tools. In BMC cancer, 19, 227. doi:10.1186/s12885-019-5406-x. https://pubmed.ncbi.nlm.nih.gov/30866865/
4. Ren, Na, Liang, Bin, Li, Yunhui. . Identification of prognosis-related genes in the tumor microenvironment of stomach adenocarcinoma by TCGA and GEO datasets. In Bioscience reports, 40, . doi:10.1042/BSR20200980. https://pubmed.ncbi.nlm.nih.gov/33015704/
5. Wu, Zenghong, Wang, Weijun, Zhang, Kun, Fan, Mengke, Lin, Rong. 2023. Epigenetic and Tumor Microenvironment for Prognosis of Patients with Gastric Cancer. In Biomolecules, 13, . doi:10.3390/biom13050736. https://pubmed.ncbi.nlm.nih.gov/37238607/
6. Wu, Haoming, Feng, Jikun, Zhong, Wenjing, Wang, Xi, Yi, Jiarong. 2023. Model for predicting immunotherapy based on M2 macrophage infiltration in TNBC. In Frontiers in immunology, 14, 1151800. doi:10.3389/fimmu.2023.1151800. https://pubmed.ncbi.nlm.nih.gov/36999020/
7. Sun, Jinrui, Feng, Qinmei, Xu, Yingying, Liu, Ping, Wu, Yumei. 2024. Analysis of prognostic value of lactate metabolism-related genes in ovarian cancer based on bioinformatics. In Journal of ovarian research, 17, 110. doi:10.1186/s13048-024-01426-z. https://pubmed.ncbi.nlm.nih.gov/38778371/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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