C57BL/6JCya-Tcp11l1em1flox/Cya
Common Name:
Tcp11l1-flox
Product ID:
S-CKO-10459
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Tcp11l1-flox
Strain ID
CKOCMP-320554-Tcp11l1-B6J-VA
Gene Name
Product ID
S-CKO-10459
Gene Alias
C130096D04Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tcp11l1em1flox/Cya mice (Catalog S-CKO-10459) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000028597
NCBI RefSeq
NM_177190
Target Region
Exon 4
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Tcp11l1, whose full name is T-complex 11 like 1, likely plays a role in biological processes related to genitourinary development and physical disability-associated pathways, though its exact functions, associated pathways and overall biological importance are not comprehensively detailed in the provided references. Genetic models could potentially be valuable for further exploring its functions.
A patient with cryptorchidism and non-obstructive azoospermia had a microdeletion at 11p13 that spanned nine genes including Tcp11l1 [1]. In a study on the association of heavy metals with activities of daily living (ADL) disability, DNA methylation at cg17485717 (annotated to Tcp11l1) mediated 30.5% of cadmium-associated ADL disability prevalence [2].
In summary, the limited research available suggests Tcp11l1 may be involved in genitourinary development as indicated by the microdeletion case in a patient with cryptorchidism and azoospermia, and in the context of ADL disability related to cadmium exposure through DNA methylation. However, more in-depth functional studies, perhaps using gene knockout (KO) or conditional knockout (CKO) mouse models, are needed to fully understand its essential biological functions and its contributions to these disease-related areas.
References:
1. Seabra, Catarina M, Quental, Sofia, Neto, Ana Paula, Amorim, António, Lopes, Alexandra M. 2014. A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia. In Reproductive biomedicine online, 29, 388-91. doi:10.1016/j.rbmo.2014.04.017. https://pubmed.ncbi.nlm.nih.gov/24912414/
2. Xiao, Lili, Cheng, Hong, Cai, Haiqing, Zou, Yunfeng, Yang, Xiaobo. 2022. Associations of Heavy Metals with Activities of Daily Living Disability: An Epigenome-Wide View of DNA Methylation and Mediation Analysis. In Environmental health perspectives, 130, 87009. doi:10.1289/EHP10602. https://pubmed.ncbi.nlm.nih.gov/36036794/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen