C57BL/6JCya-Acsbg2^em1flox/Cya

Acsbg2, a member of the acyl-CoA synthetase bubblegum family, is involved in activating fatty acids to their CoA derivatives, playing a role in fatty acid metabolism [3]. It is specifically expressed in the testis and brainstem in humans, mice, and rats [3]. In vertebrates, the Acsbg gene family, including Acsbg2, has an evolutionary history with gene expansion, retention, and loss events [4].

In chickens, miR-125b-5p can directly bind to the 3'UTR of Acsbg2, and miR-125b-5p overexpression represses Acsbg2 mRNA and protein expression. This interaction affects adipogenesis, as miR-125b-5p inhibits preadipocyte proliferation and promotes differentiation, at least partially by downregulating Acsbg2 [1]. In chicken studies, the G1257069A and T1247123C of the Acsbg2 gene were significantly associated with abdominal fat weight, indicating its role in fat deposition [6]. Also, in chicken liver, Acsbg2 was identified as a hub gene in abdominal fat weight-positively correlated modules, suggesting its importance in lipid metabolism [8].

In dairy goats, Acsbg2 was identified as a candidate gene related to milk production traits [5]. In Chinese Holstein population, a variant in Acsbg2 affected fat yield and protein percentage [7]. In early Alzheimer's disease, Acsbg2 was one of the core targets for lipid metabolism disorder [2].

In summary, Acsbg2 is crucial for fatty acid metabolism and is involved in various biological processes such as adipogenesis, fat deposition, milk production, and lipid metabolism in different species. Its study in these genetic models provides insights into its functions in normal physiological processes and disease-related lipid metabolism disorders, like in early Alzheimer's disease [1,2,5,6,7,8].