Lgr6, or leucine-rich repeat containing G protein-coupled receptor 6, is a significant gene involved in multiple biological processes. It has been linked to the Wnt signaling pathway in various contexts [4]. Lgr6 plays important roles in maintaining tissue homeostasis, stem cell regulation, and response to injury and disease, making genetic models crucial for its study.

In epidermal stem cells, Lgr6 marks a population that specializes in wound re-epithelialization. Diphtheria toxin-mediated ablation of Lgr6 stem cells delays wound healing, indicating its essential role in this process [1]. In the heart, Lgr6 knockout mice showed aggravated myocardial ischemia-reperfusion injury due to enhanced necroptosis, while overexpression had the opposite effect, suggesting Lgr6 protects against this injury by suppressing necroptosis [2]. In diabetic cardiomyopathy, Lgr6 knockout in mice aggravated cardiac dysfunction, ferroptosis, and mitochondrial disorders, while overexpression alleviated these issues, showing its role in regulating mitochondrial biogenesis and preventing ferroptosis [3].

In conclusion, Lgr6 is essential for processes like wound re-epithelialization, protection against myocardial ischemia-reperfusion injury, and alleviating diabetic cardiomyopathy. Gene knockout mouse models have been instrumental in revealing these functions, highlighting Lgr6 as a potential therapeutic target in related disease areas.