C57BL/6JCya-Lyrm4em1flox/Cya
Common Name:
Lyrm4-flox
Product ID:
S-CKO-10873
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lyrm4-flox
Strain ID
CKOCMP-380840-Lyrm4-B6J-VA
Gene Name
Product ID
S-CKO-10873
Gene Alias
Gm903
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lyrm4em1flox/Cya mice (Catalog S-CKO-10873) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000053265
NCBI RefSeq
NM_201358
Target Region
Exon 2
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
LYRM4, also known as ISD11, encodes a 11 kDa iron-sulfur cluster protein. It is crucial for maintaining the stability and activity of the human cysteine desulfurase complex NFS1-LYRM4-ACP. LYRM4 is involved in iron-sulphur cluster (ISC) biosynthesis, which is related to pathways like oxidative phosphorylation, the citric acid cycle, iron homeostasis, heme biosynthesis and DNA repair [1,2].
In hepatocellular carcinoma (LIHC), LYRM4 mRNA and protein levels are upregulated. High LYRM4 expression is related to various clinical stratifications, prognosis, and survival of LIHC patients. It is also associated with the infiltrating levels of six immune cell types, indicating its potential as a prognostic biomarker and molecular target for LIHC therapy [1]. In addition, mutations in LYRM4 can cause combined OXPHOS deficiency, affecting multiple respiratory chain complexes and other Fe-S proteins in patients [2].
In conclusion, LYRM4 is essential for ISC biosynthesis and has a significant impact on multiple biological pathways. Its role in diseases like hepatocellular carcinoma and mitochondrial disorders, as revealed through functional studies, highlights its importance in understanding disease mechanisms and potential therapeutic targets.
References：
1. Pang, Yilin, Tan, Guoqiang, Yang, Xunjun, Lyu, Jianxin, Wang, Zheng. 2021. Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma. In Cancer cell international, 21, 463. doi:10.1186/s12935-021-02131-3. https://pubmed.ncbi.nlm.nih.gov/34488769/
2. Lim, Sze Chern, Friemel, Martin, Marum, Justine E, Thorburn, David R, Compton, Alison G. 2013. Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. In Human molecular genetics, 22, 4460-73. doi:10.1093/hmg/ddt295. https://pubmed.ncbi.nlm.nih.gov/23814038/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen