C57BL/6JCya-Accslem1flox/Cya
Common Name:
Accsl-flox
Product ID:
S-CKO-10939
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Accsl-flox
Strain ID
CKOCMP-381411-Accsl-B6J-VA
Gene Name
Product ID
S-CKO-10939
Gene Alias
Gm1967
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Accslem1flox/Cya mice (Catalog S-CKO-10939) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000099690
NCBI RefSeq
NM_001033452
Target Region
Exon 3~4
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Accsl, one of the five hub genes closely related to the occurrence and development of diffuse large B-cell lymphoma (DLBCL), was identified through key driver analysis in a study on gene-expression differences between limited-and advanced-stage DLBCL patients [1]. The gene co-expression modules analysis indicated that DLBCL progression was related to pathways like the NOD-like receptor signaling pathway, neutrophil activation, and functions such as secretory granule membrane and carboxylic acid binding [1].
In this study, a pipeline was used to analyze RNA sequencing data of DLBCL patients. By performing differential gene expression analysis, weighted gene correlation network analysis, and key driver analysis, Accsl was found among the key genes related to DLBCL stage progression [1].
In conclusion, Accsl appears to be an important gene in the context of DLBCL, with its identification contributing to understanding the molecular mechanisms underlying the progression of this lymphoma. The study provides a basis for further exploration of Accsl's role in DLBCL, potentially leading to new treatment strategies.
References：
1. Xiang, Chenxi, Ni, Huimin, Wang, Zhina, Ma, Dongshen, Liu, Hui. 2021. Agent Repurposing for the Treatment of Advanced Stage Diffuse Large B-Cell Lymphoma Based on Gene Expression and Network Perturbation Analysis. In Frontiers in genetics, 12, 756784. doi:10.3389/fgene.2021.756784. https://pubmed.ncbi.nlm.nih.gov/34721544/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen