C57BL/6JCya-Zfp622em1flox/Cya
Common Name:
Zfp622-flox
Product ID:
S-CKO-11519
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Zfp622-flox
Strain ID
CKOCMP-52521-Zfp622-B6J-VA
Gene Name
Product ID
S-CKO-11519
Gene Alias
1110033B05Rik; D15Ertd806e; ZPR9; Znf622
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp622em1flox/Cya mice (Catalog S-CKO-11519) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000061875
NCBI RefSeq
NM_144523
Target Region
Exon 2~3
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Zfp622, a gene whose full function and associated pathways are yet to be comprehensively defined, is likely involved in various biological processes. Its study through genetic models could potentially provide in-depth insights into its role in normal biological function and disease mechanisms.
In a study on panic disorder, exploratory analyses based on biological validity and a combined statistical/biological ranking suggested dynamic methylation of the ZFP622 gene along with response to cognitive-behavioral therapy (CBT), indicating its possible involvement in the epigenetic mechanisms related to panic disorder [1]. In another study on Pekin duck, ZFP622 had high expression levels at 6 weeks old in breast muscle, suggesting its possible role in breast muscle development in ducks [2].
In conclusion, Zfp622 seems to be associated with both epigenetic regulation in panic disorder and breast muscle development in Pekin ducks. The study of Zfp622 using genetic models, such as KO or CKO mouse models (not yet explored in the provided references but could be valuable in future research), could potentially further clarify its role in these and other disease-related or developmental biological processes.
References:
1. Ziegler, Christiane, Grundner-Culemann, Franziska, Schiele, Miriam A, Köttgen, Anna, Domschke, Katharina. 2019. The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study. In Translational psychiatry, 9, 314. doi:10.1038/s41398-019-0648-6. https://pubmed.ncbi.nlm.nih.gov/31754096/
2. Xu, Tieshan, Huang, Wei, Zhang, Xiaohui, Zhou, Hanlin, Hou, Shuisheng. 2012. Identification and characterization of genes related to the development of breast muscles in Pekin duck. In Molecular biology reports, 39, 7647-55. doi:10.1007/s11033-012-1599-7. https://pubmed.ncbi.nlm.nih.gov/22451153/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen