C57BL/6JCya-Ldlrad4em1flox/Cya
Common Name
Ldlrad4-flox
Product ID
S-CKO-11541
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-52662-Ldlrad4-B6J-VA
When using this mouse strain in a publication, please cite “Ldlrad4-flox Mouse (Catalog S-CKO-11541) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ldlrad4-flox
Strain ID
CKOCMP-52662-Ldlrad4-B6J-VA
Gene Name
Product ID
S-CKO-11541
Gene Alias
8230401C20Rik, A430083H02, A430108L08Rik, C18orf1, D18Ertd653e, D330030L18Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 18
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000063775
NCBI RefSeq
NM_172631
Target Region
Exon 4
Size of Effective Region
~1.5 kb
Overview of Gene Research
Ldlrad4, or low-density lipoprotein receptor class A domain-containing protein 4, has been implicated in multiple biological processes. Structurally similar to TMEPAI, its protein might be involved in lipid metabolism-related pathways [3,5]. It has also been associated with psychiatric disorders [3]. Its role in biological processes makes it an important gene for understanding normal physiological functions and disease mechanisms.
In cancer research, Ldlrad4 shows complex roles. In colorectal cancer, the antisense lncRNA LDLRAD4-AS1 can decrease the expression of Ldlrad4, promoting metastasis through epithelial-to-mesenchymal transition (EMT) via upregulating Snail [1]. In hepatic cancer, Ldlrad4 is elevated and promotes cell proliferation and migration, interacting with Nedd4 and negatively regulating the TGF-β signaling [3]. In the liver of rats treated with nongenotoxic hepatocarcinogens, downregulation of Ldlrad4 induces TGF-β signaling, promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis [2]. In primary gastrointestinal stromal tumors, Ldlrad4 expression is an independent prognostic factor for recurrence-free survival [4].
In conclusion, Ldlrad4 is involved in multiple important biological processes, especially in cancer-related pathways such as cell proliferation, migration, and metastasis. The study of Ldlrad4 through various genetic models helps to understand its role in disease development, providing potential insights for diagnosis, prognosis, and treatment in cancer and other diseases where it is implicated.
References：
1. Mo, Shaobo, Zhang, Long, Dai, Weixing, Cai, Sanjun, Cai, Guoxiang. 2020. Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer. In Cell death & disease, 11, 155. doi:10.1038/s41419-020-2338-y. https://pubmed.ncbi.nlm.nih.gov/32111819/
2. Ito, Yuko, Nakajima, Kota, Masubuchi, Yasunori, Yoshida, Toshinori, Shibutani, Makoto. 2020. Downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis. In Journal of applied toxicology : JAT, 40, 1467-1479. doi:10.1002/jat.3998. https://pubmed.ncbi.nlm.nih.gov/32596862/
3. Liu, Zhenxing, Huo, Xin, Zhao, Shuang, Gao, Yingtang, Diao, Aipo. 2017. Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells. In Experimental cell research, 360, 189-198. doi:10.1016/j.yexcr.2017.09.005. https://pubmed.ncbi.nlm.nih.gov/28888937/
4. Xie, Wei, Xiao, He, Luo, Jia, Chen, Chuan, Wang, Ge. 2020. Identification of low-density lipoprotein receptor class A domain containing 4 (LDLRAD4) as a prognostic indicator in primary gastrointestinal stromal tumors. In Current problems in cancer, 44, 100593. doi:10.1016/j.currproblcancer.2020.100593. https://pubmed.ncbi.nlm.nih.gov/32507364/
5. Hong, Kyung-Won, Shin, Myung-Seop, Ahn, Yoo-Been, Lee, Hyun-Jin, Kim, Hyun-Duck. 2015. Genomewide association study on chronic periodontitis in Korean population: results from the Yangpyeong health cohort. In Journal of clinical periodontology, 42, 703-710. doi:10.1111/jcpe.12437. https://pubmed.ncbi.nlm.nih.gov/26212799/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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