C57BL/6JCya-Sult1d1em1flox/Cya
Common Name:
Sult1d1-flox
Product ID:
S-CKO-11579
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Sult1d1-flox
Strain ID
CKOCMP-53315-Sult1d1-B6J-VA
Gene Name
Product ID
S-CKO-11579
Gene Alias
5033411P13Rik; ST1d1; SULT-N; Sultn
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sult1d1em1flox/Cya mice (Catalog S-CKO-11579) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000113314
NCBI RefSeq
NM_016771
Target Region
Exon 3~4
Size of Effective Region
~2.2 kb
Detailed Document
Overview of Gene Research
Sult1d1 is a sulfotransferase gene, a member of the large superfamily of detoxification enzymes. It plays a crucial role in inactivating endogenous dopamine-derived compounds, especially catecholamines, and is involved in pathways related to stress response and metabolic regulation. Genetic models, such as knockout mouse models, are valuable tools for studying its functions [1].
In mice, Sult1d1 knockout led to a 99% decrease in renal activation of the genotoxicant 1-hydroxymethylpyrene, verifying its role in the metabolic activation of this compound in the kidney [2]. In another study, knocking out Sult1d1 along with Sult1a1 almost totally eliminated the gender gap in bladder susceptibility to the human carcinogen 4-aminobiphenyl (ABP) in mice, suggesting Sult1d1's role in promoting ABP-DNA adduct formation in hepatic cells [3]. However, the Sult1d1 knockout did not influence the formation of hemoglobin adducts of furfuryl alcohol [4].
In conclusion, Sult1d1 is essential for the inactivation of catecholamines and plays a role in the metabolic activation of certain genotoxicants and carcinogens. Gene knockout mouse models have been instrumental in revealing its functions in specific biological processes related to chemical activation and carcinogen-induced tissue susceptibility.
References:
1. Wong, Stephen, Tan, Kheng, Carey, Kirstyn T, Tiganis, Tony, Cole, Timothy J. 2009. Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1. In Endocrinology, 151, 185-94. doi:10.1210/en.2009-0590. https://pubmed.ncbi.nlm.nih.gov/19966186/
2. Bendadani, Carolin, Meinl, Walter, Monien, Bernhard, Himmelbauer, Heinz, Glatt, Hansruedi. 2014. Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models. In Chemical research in toxicology, 27, 1060-9. doi:10.1021/tx500129g. https://pubmed.ncbi.nlm.nih.gov/24802129/
3. Li, Yun, Chen, Zhidan, Paonessa, Joseph D, Vouros, Paul, Zhang, Yuesheng. 2018. Strong impact of sulfotransferases on DNA adduct formation by 4-aminobiphenyl in bladder and liver in mice. In Cancer medicine, 7, 5604-5610. doi:10.1002/cam4.1779. https://pubmed.ncbi.nlm.nih.gov/30306738/
4. Monien, Bernhard H, Sachse, Benjamin, Meinl, Walter, Lampen, Alfonso, Glatt, Hansruedi. 2018. Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2. In Toxicology letters, 295, 173-178. doi:10.1016/j.toxlet.2018.06.008. https://pubmed.ncbi.nlm.nih.gov/29908303/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen