C57BL/6JCya-Avpr1aem1flox/Cya
Common Name:
Avpr1a-flox
Product ID:
S-CKO-11691
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Avpr1a-flox
Strain ID
CKOCMP-54140-Avpr1a-B6J-VA
Gene Name
Product ID
S-CKO-11691
Gene Alias
AVPR; Avpr1; V1a; V1aR
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Avpr1aem1flox/Cya mice (Catalog S-CKO-11691) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020323
NCBI RefSeq
NM_016847
Target Region
Exon 1
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Avpr1a, the arginine vasopressin receptor 1A gene, encodes a receptor that interacts with the arginine vasopressin hormone. It is involved in physiological stress regulation, blood pressure control, and child development. It also plays a role in maintaining homeostasis and regulating social behavior. The neuropeptide arginine vasopressin (AVP) which binds to AVPR1A has significant functions in the body, and understanding Avpr1a helps in uncovering the mechanisms of related biological processes [1,2].
In a mouse model study, specific AVPR1A ligand binding was observed in the neonatal mouse periphery in sensory tissues of the head, bone, spinal cord, adrenal cortex, and the uro-anogenital region in wildtype mice, but significantly reduced or absent in AVPR1A knockout mice, suggesting AVPR1A's role in modulating neonatal peripheral physiology and development [2]. In female mice, loss-of-function studies demonstrated that AVPR1A signaling in the central nucleus of the amygdala is required for the effects of chronic social isolation stress on anxiety-related behaviors, while having no effect in males or group-housed females [3].
In conclusion, Avpr1a is crucial for physiological stress regulation, blood pressure, child development, and neonatal peripheral physiology and development. Its role in female-specific susceptibility to chronic social isolation-induced anxiety-related behaviors has also been revealed through mouse models. These findings contribute to understanding the mechanisms underlying these biological processes and potential implications for related health conditions.
References:
1. Nidey, Nichole, Bowers, Katherine, Ding, Lili, Mahabee-Gittens, E Melinda, Folger, Alonzo T. 2023. Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking. In Toxics, 11, . doi:10.3390/toxics11100855. https://pubmed.ncbi.nlm.nih.gov/37888705/
2. Day, Katherine R, Coleman, Alexis, Greenwood, Maria A, Hammock, Elizabeth A D. 2020. AVPR1A distribution in the whole C57BL/6J mouse neonate. In Scientific reports, 10, 14512. doi:10.1038/s41598-020-71392-1. https://pubmed.ncbi.nlm.nih.gov/32884025/
3. François, Marie, Delgado, Isabella Canal, Lafond, Alexandre, Dölen, Gül, Zeltser, Lori M. 2023. Amygdala AVPR1A mediates susceptibility to chronic social isolation in females. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.02.15.528679. https://pubmed.ncbi.nlm.nih.gov/36824966/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen