C57BL/6JCya-Adgrg3em1flox/Cya
Common Name
Adgrg3-flox
Product ID
S-CKO-11857
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-54672-Adgrg3-B6J-VA
When using this mouse strain in a publication, please cite “Adgrg3-flox Mouse (Catalog S-CKO-11857) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Adgrg3-flox
Strain ID
CKOCMP-54672-Adgrg3-B6J-VA
Gene Name
Product ID
S-CKO-11857
Gene Alias
A030001G24Rik, Gpr97, Pb1, Pb99
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000051259
NCBI RefSeq
NM_173036
Target Region
Exon 4~8
Size of Effective Region
~3.1 kb
Overview of Gene Research
Adgrg3, also known as GPR97, is an adhesion G-protein-coupled receptor. It plays roles in regulating cytokine expression, and is involved in the NF-κB signaling pathway. It is expressed in various cells like granulocytes and has significance in host defense and immune-related biological processes [1,2,3].
Using an Adgrg3-knockout mouse model, researchers found that Adgrg3-deficient (Adgrg3-/ -) mice with experimental autoimmune encephalomyelitis (EAE) had increased peak severity and cumulative disease scores. There was also more leukocyte infiltration, extensive demyelination, and an increase in Th1/Th17 cells in the CNS accompanied by high levels of pro-inflammatory cytokines, indicating its importance in the development of EAE [2].
In conclusion, Adgrg3 is crucial in regulating cytokine expression and plays a significant role in EAE, an inflammatory disease of the central nervous system. The Adgrg3-knockout mouse model has been instrumental in revealing its function in this disease area, providing insights into potential therapeutic strategies for CNS autoimmunity [2].
References：
1. Hamann, Jörg, Aust, Gabriela, Araç, Demet, Langenhan, Tobias, Schiöth, Helgi B. . International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. In Pharmacological reviews, 67, 338-67. doi:10.1124/pr.114.009647. https://pubmed.ncbi.nlm.nih.gov/25713288/
2. Wang, Jinjin, Wang, Xiyi, Chen, Xuejiao, Fei, Jian, Wang, Zhugang. . Gpr97/Adgrg3 ameliorates experimental autoimmune encephalomyelitis by regulating cytokine expression. In Acta biochimica et biophysica Sinica, 50, 666-675. doi:10.1093/abbs/gmy060. https://pubmed.ncbi.nlm.nih.gov/29860267/
3. Hsiao, Cheng-Chih, Chu, Tai-Ying, Wu, Chia-Jung, Hamann, Jörg, Lin, Hsi-Hsien. 2018. The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions. In Frontiers in immunology, 9, 2830. doi:10.3389/fimmu.2018.02830. https://pubmed.ncbi.nlm.nih.gov/30559745/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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