Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Rcan1em1flox/Cya
Common Name:
Rcan1-flox
Product ID:
S-CKO-11875
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Rcan1-flox
Strain ID
CKOCMP-54720-Rcan1-B6J-VA
Gene Name
Rcan1
Product ID
S-CKO-11875
Gene Alias
Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1; RCN1
Background
C57BL/6JCya
NCBI ID
54720
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:1890564
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rcan1em1flox/Cya mice (Catalog S-CKO-11875) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000060005
NCBI RefSeq
NM_001081549.2
Target Region
Exon 2~3
Size of Effective Region
~2.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rcan1, short for Regulator of calcineurin 1, is a crucial gene with its primary function being the inhibition of the phosphatase calcineurin, and it also regulates mitochondrial function [4]. It is involved in pathways such as the calcineurin/NFAT transcriptional pathway, and plays a significant role in various biological processes including synaptic plasticity, development and maintenance of the cardiovascular system, and is associated with multiple diseases [4,5]. Genetic models like KO/CKO mouse models are valuable for studying Rcan1.

In cardiovascular diseases, RCAN1 reduction protects against atherosclerosis by reducing the uptake of oxidized low-density lipoproteins, while RCAN1 has a protective effect on myocardial ischemia/reperfusion injury, myocardial hypertrophy and intramural hematoma/aortic rupture [1]. In septic cardiomyopathy, RCAN1 -/- mice showed severe cardiac function impairment, increased myocardial hypertrophy and fibrosis, and aggravated mitochondrial injury, indicating that RCAN1 deficiency worsens the condition [3]. In diabetic cardiomyopathy, knockdown of RCAN1 improved cardiac dysfunction, lipid accumulation, and mitochondrial fission in db/db mice [2].

In conclusion, Rcan1 is essential in regulating mitochondrial function and calcineurin activity. Studies using KO/CKO mouse models have revealed its roles in cardiovascular diseases, septic cardiomyopathy, and diabetic cardiomyopathy. Understanding Rcan1 through these models provides insights into the mechanisms of these diseases and potential therapeutic strategies.

References:
1. Wang, Shuai, Wang, Yuqing, Qiu, Kaixin, Zhu, Jin, Wu, Yili. 2020. RCAN1 in cardiovascular diseases: molecular mechanisms and a potential therapeutic target. In Molecular medicine (Cambridge, Mass.), 26, 118. doi:10.1186/s10020-020-00249-0. https://pubmed.ncbi.nlm.nih.gov/33267791/
2. Shu, Songren, Cui, Hao, Liu, Zirui, Hu, Shengshou, Song, Jiangping. 2024. Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy. In Metabolism: clinical and experimental, 158, 155977. doi:10.1016/j.metabol.2024.155977. https://pubmed.ncbi.nlm.nih.gov/39053690/
3. Zhuang, Jinqiang, Chen, Liming, Li, Gongke, Wang, Shijun, Yuan, Ruijun. 2022. RCAN1 deficiency aggravates sepsis-induced cardiac remodeling and dysfunction by accelerating mitochondrial pathological fission. In Inflammation research : official journal of the European Histamine Research Society ... [et al.], 71, 1589-1602. doi:10.1007/s00011-022-01628-5. https://pubmed.ncbi.nlm.nih.gov/36305917/
4. Peiris, Heshan, Keating, Damien J. 2017. The neuronal and endocrine roles of RCAN1 in health and disease. In Clinical and experimental pharmacology & physiology, 45, 377-383. doi:10.1111/1440-1681.12884. https://pubmed.ncbi.nlm.nih.gov/29094385/
5. Dudilot, Anthony, Trillaud-Doppia, Emilie, Boehm, Jannic. 2020. RCAN1 Regulates Bidirectional Synaptic Plasticity. In Current biology : CB, 30, 1167-1176.e2. doi:10.1016/j.cub.2020.01.041. https://pubmed.ncbi.nlm.nih.gov/32084406/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest